{"product_id":"slc11a2-antibody-solute-carrier-family-11-member-2-bha17128154","title":"SLC11A2 Antibody \/ Solute carrier family 11 member 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eSLC11A2 Antibody \/ Solute carrier family 11 member 2 is an antibody targeting \u003cstrong\u003eSLC11A2\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLC11A2 (reported localization: Cytoplasm).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human, Mouse, Rat.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB, IF (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eSLC11A2, also known as Solute carrier family 11 member 2 and Divalent metal ion transporter 1 (DMT1), SLC11A2 is responsible for transporting essential metal ions, such as iron and manganese, across cell membranes. These metal ions are vital for various biological processes, including oxygen transport, energy production, and DNA synthesis. Research has shown that mutations in the SLC11A2 gene can lead to various health conditions, such as iron-deficiency anemia and neurodegenerative disorders.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eImmunofluorescence: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry P49281 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P49281 - Gene search: SLC11A2 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLC11A2 - Ensembl search: SLC11A2 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLC11A2 - PubMed search: SLC11A2 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLC11A2+antibody - Reactome search: SLC11A2 — Reactome — https:\/\/reactome.org\/content\/query?q=SLC11A2 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53046411264365,"sku":"F55091-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53046470639981,"sku":"F55091-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_cb625459-0562-4aaa-b6bc-2e06d1a585cd.jpg?v=1772000492","url":"https:\/\/www.ebiohippo.com\/products\/slc11a2-antibody-solute-carrier-family-11-member-2-bha17128154","provider":"BioHippo","version":"1.0","type":"link"}