{"product_id":"slc14a1-antibody-urea-transporter-1-ut-b-bha17135276","title":"SLC14A1 Antibody \/ Urea transporter 1 \/ UT-B","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLC14A1 Antibody \/ Urea transporter 1 \/ UT-B is a anti-SLC14A1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Immunohistochemistry (IHC), Western blot (WB), Flow cytometry (FACS) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLC14A1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e ELISA, IHC, WB, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe SLC14A1 antibody targets Urea transporter 1 (UT-B), a membrane channel encoded by the SLC14A1 gene. Urea transporter 1 facilitates rapid, passive transport of urea across cell membranes, maintaining osmotic balance in tissues such as the kidney, red blood cells, and bladder. As a member of the solute carrier family, Urea transporter 1 is integral to urinary concentrating mechanisms and nitrogen metabolism. The SLC14A1 antibody provides a valuable reagent for studying renal physiology, erythrocyte transport, and metabolic homeostasis.\u003cbr\u003e\u003cbr\u003eUrea transporter 1 is highly expressed in erythrocytes, renal descending vasa recta, and bladder epithelium, where it regulates urea permeability and water reabsorption. The protein forms a transmembrane channel composed of multiple membrane-spanning helices that enable facilitated urea diffusion without energy expenditure. The SLC14A1 antibody allows visualization of this transporter in tissue sections and cell membranes, offering insight into how urea flux contributes to osmoregulation and urinary concentration.\u003cbr\u003e\u003cbr\u003eGenetic polymorphisms in SLC14A1 have been linked to differences in erythrocyte antigen systems (the Kidd blood group, JK), as well as altered susceptibility to hemolysis and bladder cancer. The SLC14A1 antibody aids in detecting protein variants and assessing their expression patterns. In the kidney, Urea transporter 1 cooperates with aquaporins to control medullary osmolarity, optimizing urine concentration during water deprivation. Studies using this antibody have clarified how transporter regulation by hormones such as vasopressin adjusts urea recycling to maintain fluid balance.\u003cbr\u003e\u003cbr\u003eBeyond its renal role, Urea transporter 1 participates in nitrogen balance and tissue detoxification. In erythrocytes, it ensures rapid equilibration of plasma and cytosolic urea concentrations, preventing osmotic stress. The SLC14A1 antibody is a key reagent for investigating how transporter dysfunction affects blood cell stability, renal concentrating ability, and urinary tract physiology. It also helps characterize SLC14A1 expression changes associated with metabolic disorders, dehydration, and cancer.\u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLC14A1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLC14A1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLC14A1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLC14A1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLC14A1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047285809517,"sku":"FY12373","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f42dfc02-52d1-4720-9027-1c5903f78a73.jpg?v=1782236990","url":"https:\/\/www.ebiohippo.com\/products\/slc14a1-antibody-urea-transporter-1-ut-b-bha17135276","provider":"BioHippo","version":"1.0","type":"link"}