{"product_id":"slc15a5-antibody-solute-carrier-family-15-member-5-bha17136163","title":"SLC15A5 Antibody \/ Solute carrier family 15 member 5","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLC15A5 Antibody \/ Solute carrier family 15 member 5 is a anti-SLC15A5 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLC15A5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSLC15A5 antibody detects Solute carrier family 15 member 5, a member of the proton-coupled oligopeptide transporter family that contributes to peptide transport across cellular membranes. The UniProt recommended name is Solute carrier family 15 member 5 (SLC15A5). This membrane protein is primarily expressed in the brain and functions in the uptake and recycling of small peptides, potentially influencing neuronal signaling and metabolic homeostasis.\u003cbr\u003e\u003cbr\u003eFunctionally, SLC15A5 antibody identifies a 579-amino-acid transmembrane transporter characterized by multiple hydrophobic segments that form a peptide permeation pathway. While the physiological substrates of SLC15A5 remain under investigation, its sequence homology with other SLC15 family members (such as SLC15A1\/PEPT1 and SLC15A2\/PEPT2) suggests it operates as a proton-dependent symporter. SLC15A5 likely participates in regulating peptide and amino acid availability in neuronal and glial cells, supporting neurotransmitter synthesis and signaling balance.\u003cbr\u003e\u003cbr\u003eThe SLC15A5 gene is located on chromosome 12q21.31 and is expressed primarily in the central nervous system, with highest levels observed in cerebellum and hippocampus. Expression is tightly regulated during neural development and may respond to metabolic or synaptic activity changes. In addition to its neuronal role, SLC15A5 expression has been reported in skeletal muscle and testis, indicating potential tissue-specific transport functions.\u003cbr\u003e\u003cbr\u003ePathologically, disruption of SLC15A5 expression has been linked to neurological and psychiatric conditions. Variants in the SLC15A5 locus have been associated with susceptibility to major depressive disorder and cognitive dysfunction. Abnormal transporter activity may affect brain peptide signaling and synaptic communication. Research using SLC15A5 antibody supports studies in membrane transport, neurobiology, and metabolic regulation.\u003cbr\u003e\u003cbr\u003eSLC15A5 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect peptide transport proteins. \u003cbr\u003e\u003cbr\u003eStructurally, Solute carrier family 15 member 5 contains 12 predicted transmembrane helices forming a transporter channel and cytoplasmic domains involved in proton coupling and regulation. Conserved motifs typical of the SLC15 family mediate substrate binding and conformational shifts during the transport cycle. This antibody enables investigation of SLC15A5's role in neuronal physiology, peptide metabolism, and cellular transport processes.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLC15A5 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLC15A5 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLC15A5 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLC15A5 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLC15A5+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047321198957,"sku":"FY13261","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d4181d39-000b-41d8-bbed-24fe4a14de7e.jpg?v=1782237079","url":"https:\/\/www.ebiohippo.com\/products\/slc15a5-antibody-solute-carrier-family-15-member-5-bha17136163","provider":"BioHippo","version":"1.0","type":"link"}