{"product_id":"slc16a1-antibody-monocarboxylate-transporter-1-mct1-bha17136301","title":"SLC16A1 Antibody \/ Monocarboxylate transporter 1 \/ MCT1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLC16A1 Antibody \/ Monocarboxylate transporter 1 \/ MCT1 is a anti-SLC16A1 Rabbit antibody Recombinant Rabbit Monoclonal clone 20S76 supplied in Purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Human. Reported localization: Cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLC16A1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 20S76, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSLC16A1 (also called Monocarboxylate transporter 1 and MCT1) is a 12-transmembrane monocarboxylate\/proton symporter that mediates bidirectional transport of lactate, pyruvate, and ketone bodies across the plasma membrane. Coupled to H\u003csup\u003e+\u003c\/sup\u003e gradients and aided by the chaperone basigin\/CD147, SLC16A1 maintains cellular redox balance, supports glycolysis-oxidative coupling between cells, and contributes to pH homeostasis in metabolically active tissues.\u003cp\u003eSLC16A1 is broadly expressed, with high levels in skeletal muscle, cardiac muscle, erythrocytes, endothelium, and select immune and epithelial cells. Its activity underlies lactate shuttle biology and metabolic symbiosis, making it a useful readout in studies of exercise physiology, hypoxia responses, and metabolic remodeling under defined experimental conditions.\u003c\/p\u003e\n\u003cp\u003eThe \u003cb\u003eSLC16A1 antibody\u003c\/b\u003e enables specific detection of endogenous MCT1 in applications such as western blot, immunofluorescence, immunohistochemistry, and flow cytometry. Researchers use the SLC16A1 antibody from\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLC16A1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLC16A1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLC16A1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLC16A1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLC16A1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047325360493,"sku":"RQ8882","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_299ef77d-94f6-4ee7-a4f0-da505f56dc84.jpg?v=1772019441","url":"https:\/\/www.ebiohippo.com\/products\/slc16a1-antibody-monocarboxylate-transporter-1-mct1-bha17136301","provider":"BioHippo","version":"1.0","type":"link"}