{"product_id":"slc17a6-antibody-vglut2-vesicular-glutamate-transporter-2-bha17135484","title":"SLC17A6 Antibody \/ VGLUT2 \/ Vesicular glutamate transporter 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLC17A6 Antibody \/ VGLUT2 \/ Vesicular glutamate transporter 2 is a anti-SLC17A6 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLC17A6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSLC17A6 antibody detects Vesicular glutamate transporter 2 (VGLUT2), a membrane protein responsible for packaging the excitatory neurotransmitter glutamate into synaptic vesicles. SLC17A6 plays a central role in excitatory neurotransmission throughout the central nervous system, determining the quantal content of glutamatergic synapses. The SLC17A6 antibody is widely used in neuroscience research to study synaptic physiology, neurotransmitter transport, and neural circuit organization.\u003cbr\u003e\u003cbr\u003eSLC17A6 is encoded by the SLC17A6 gene located on human chromosome 11p14. The protein is approximately 582 amino acids long and belongs to the solute carrier 17 family of sodium-dependent phosphate transporters. SLC17A6 localizes to presynaptic vesicles in excitatory neurons, where it uses a proton electrochemical gradient to drive the uptake of glutamate into vesicles prior to release. Its activity directly influences synaptic strength and excitatory signaling fidelity.\u003cbr\u003e\u003cbr\u003eAn SLC17A6 antibody detects a 60 kilodalton band by western blot and reveals punctate presynaptic staining in neurons and neuropil under immunofluorescence. SLC17A6 expression is region-specific, being highly enriched in subcortical brain regions such as the thalamus, brainstem, and hypothalamus. This distribution distinguishes it from the related vesicular glutamate transporters SLC17A7 (VGLUT1) and SLC17A8 (VGLUT3), which have complementary roles in different neuronal populations.\u003cbr\u003e\u003cbr\u003eFunctionally, SLC17A6 controls the rate of glutamate release and synaptic efficacy. Knockout studies demonstrate that loss of SLC17A6 leads to severe impairment in excitatory neurotransmission, altered locomotor behavior, and perinatal lethality. Conversely, increased expression of SLC17A6 enhances glutamatergic tone, contributing to excitotoxicity in neurodegenerative disorders such as Parkinson's and Alzheimer's disease.\u003cbr\u003e\u003cbr\u003eBeyond its neuronal function, SLC17A6 is expressed in certain endocrine tissues, where it contributes to glutamate-dependent signaling. Because of its precise localization and critical role in neurotransmitter loading, SLC17A6 serves as a robust marker for excitatory synapses.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLC17A6 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLC17A6 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLC17A6 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLC17A6 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLC17A6+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047293051245,"sku":"FY12581","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d0ffd97f-083c-42ba-bee4-ba83cbb5631d.jpg?v=1782237024","url":"https:\/\/www.ebiohippo.com\/products\/slc17a6-antibody-vglut2-vesicular-glutamate-transporter-2-bha17135484","provider":"BioHippo","version":"1.0","type":"link"}