{"product_id":"slc27a2-antibody-fatp2-bha17135778","title":"SLC27A2 Antibody \/ FATP2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLC27A2 Antibody \/ FATP2 is a anti-SLC27A2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm (ER), cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLC27A2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSLC27A2 antibody detects Long-chain fatty acid transport protein 2 (FATP2), an enzyme and transporter that mediates cellular uptake and activation of long-chain and very-long-chain fatty acids. Encoded by the SLC27A2 gene on chromosome 15q21.2, this bifunctional protein possesses both acyl-CoA synthetase and membrane transporter activity, coupling fatty acid import with activation into acyl-CoA thioesters. FATP2 plays a central role in lipid metabolism, peroxisomal beta-oxidation, and energy balance.\u003cbr\u003e\u003cbr\u003eStructurally, FATP2 is an integral membrane protein of approximately 70 kilodaltons containing an AMP-binding domain and a transmembrane domain that anchors it to the endoplasmic reticulum and peroxisomal membranes. By simultaneously transporting and esterifying fatty acids, FATP2 ensures efficient channeling of lipids into metabolic and anabolic pathways. It exhibits substrate preference for long-chain and polyunsaturated fatty acids, regulating lipid composition in liver and kidney tissues where it is abundantly expressed.\u003cbr\u003e\u003cbr\u003eThe SLC27A2 antibody is widely used in lipid metabolism, endocrinology, and mitochondrial research to study fatty acid transport, oxidation, and storage. Western blot analysis detects a 70 kilodalton band corresponding to FATP2, while immunofluorescence reveals peroxisomal and ER-associated staining. This antibody is an essential reagent for investigating lipid homeostasis and the mechanisms linking fatty acid uptake to metabolic regulation.\u003cbr\u003e\u003cbr\u003eFATP2 expression is upregulated in metabolic and inflammatory conditions, including nonalcoholic fatty liver disease and insulin resistance. Its deficiency disrupts fatty acid activation and leads to altered lipid accumulation, oxidative stress, and impaired peroxisomal function. In cancer cells, FATP2 supports rapid proliferation by promoting fatty acid uptake and lipid synthesis, making it a potential therapeutic target in metabolic oncology. The SLC27A2 antibody provides a reliable tool for detecting FATP2 expression, studying fatty acid channeling, and evaluating its role in disease-associated metabolic remodeling.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLC27A2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLC27A2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLC27A2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLC27A2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLC27A2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047304257901,"sku":"FY12876","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_7de9c41c-c97d-456e-861c-6f68e8102344.jpg?v=1782237045","url":"https:\/\/www.ebiohippo.com\/products\/slc27a2-antibody-fatp2-bha17135778","provider":"BioHippo","version":"1.0","type":"link"}