{"product_id":"slc27a4-antibody-fatp4-solute-carrier-family-27-member-4-bha17136132","title":"SLC27A4 Antibody \/ FATP4 \/ Solute carrier family 27 member 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLC27A4 Antibody \/ FATP4 \/ Solute carrier family 27 member 4 is a anti-SLC27A4 Rabbit antibody Recombinant Rabbit Monoclonal clone 30S71 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLC27A4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30S71, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSLC27A4 antibody detects Solute carrier family 27 member 4, encoded by the SLC27A4 gene. Also known as FATP4 (Fatty acid transport protein 4), this integral membrane enzyme mediates the uptake and activation of long-chain and very long-chain fatty acids. By coupling transport with acyl-CoA synthetase activity, SLC27A4\/FATP4 plays a central role in lipid metabolism, skin barrier formation, and energy homeostasis. SLC27A4 antibody provides researchers with an essential tool to study fatty acid utilization in metabolic and epithelial systems.\u003cbr\u003e\u003cbr\u003eFunctionally, FATP4 antibody recognizes a 643-amino-acid multi-pass membrane protein localized to the endoplasmic reticulum and plasma membrane. SLC27A4 catalyzes both the import of exogenous fatty acids and their subsequent activation to acyl-CoA derivatives, which are required for lipid synthesis and beta-oxidation. Research using SLC27A4\/FATP4 antibody has shown strong expression in skin keratinocytes and intestinal epithelia, where it supports lipid absorption and epidermal barrier integrity. This dual transporter-enzyme function ensures that fatty acids entering the cell are rapidly converted into metabolically usable forms.\u003cbr\u003e\u003cbr\u003ePathogenic variants in SLC27A4 (FATP4) cause ichthyosis prematurity syndrome, a rare autosomal recessive disorder marked by premature birth, respiratory distress, and defective skin barrier formation. Studies using FATP4 antibody demonstrate that loss of function disrupts epidermal lipid organization and compromises barrier cohesion, confirming the essential role of SLC27A4 in cutaneous and epithelial health.\u003cbr\u003e\u003cbr\u003eBeyond congenital disease, altered SLC27A4\/FATP4 expression has been implicated in obesity, diabetes, and cancer. Dysregulated fatty acid transport and activation can shift cellular energy balance, promoting insulin resistance and supporting tumor lipid demands. Research employing SLC27A4 antibody has linked elevated FATP4 activity to enhanced fatty acid uptake and metabolic reprogramming in malignant cells, highlighting its potential as a therapeutic target in metabolic and oncogenic pathways.\u003cbr\u003e\u003cbr\u003eSLC27A4 antibody and FATP4 antibody reagents can be validated for western blotting, immunohistochemistry, and immunofluorescence to evaluate protein expression and localization. Western blotting confirms the ~72 kDa band expected for the full-length protein, immunohistochemistry highlights strong staining in skin and intestinal tissues, and immunofluorescence visualizes membrane-associated distribution. These complementary applications make the antibody a reliable marker for studying lipid transport and metabolic regulation.\u003cbr\u003e\u003cbr\u003eBy providing validated SLC27A4\/FATP4 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLC27A4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLC27A4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLC27A4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLC27A4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLC27A4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047319200109,"sku":"FY13230","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c6c08202-169e-484d-b495-d77b4fabea05.jpg?v=1772019416","url":"https:\/\/www.ebiohippo.com\/products\/slc27a4-antibody-fatp4-solute-carrier-family-27-member-4-bha17136132","provider":"BioHippo","version":"1.0","type":"link"}