{"product_id":"slc30a8-antibody-znt8-zinc-transporter-8-bha17135822","title":"SLC30A8 Antibody \/ ZNT8 \/ Zinc transporter 8","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLC30A8 Antibody \/ ZNT8 \/ Zinc transporter 8 is a anti-SLC30A8 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Immunohistochemistry (IHC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLC30A8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSLC30A8 antibody detects Zinc transporter 8, a pancreatic beta-cell-specific membrane protein that mediates zinc transport into insulin secretory granules. Encoded by the SLC30A8 gene on chromosome 8q24.11, this transporter belongs to the solute carrier family 30 (SLC30), which regulates intracellular zinc homeostasis. Zinc transported by ZNT8 is essential for insulin crystallization, storage, and secretion, making this protein a key regulator of glucose metabolism and endocrine function.\u003cbr\u003e\u003cbr\u003eStructurally, ZNT8 is a 369-amino-acid multi-pass membrane protein of approximately 41 kilodaltons containing six transmembrane domains and a cytosolic C-terminus that mediates zinc ion transport driven by proton exchange. It localizes specifically to insulin granule membranes in pancreatic beta cells, where it sequesters zinc into vesicles, facilitating insulin hexamer formation and regulated exocytosis. ZNT8 expression is controlled by glucose and insulin signaling, reflecting its integration into metabolic feedback loops.\u003cbr\u003e\u003cbr\u003eThe SLC30A8 antibody is widely used in endocrinology, diabetes, and metabolism research to study zinc transport, insulin secretion, and beta-cell physiology. Western blot analysis detects a 41 kilodalton band corresponding to ZNT8, while immunofluorescence reveals granular cytoplasmic staining restricted to pancreatic islets. This antibody provides an excellent tool for exploring beta-cell biology and identifying autoantibody targets in diabetes pathogenesis.\u003cbr\u003e\u003cbr\u003eLoss-of-function mutations in SLC30A8 reduce zinc transport activity and have been associated with altered diabetes risk. While some variants protect against type 2 diabetes by enhancing beta-cell resilience, others increase susceptibility by impairing insulin maturation and secretion. ZNT8 is also a major autoantigen in type 1 diabetes, with circulating autoantibodies serving as biomarkers for early disease detection. The SLC30A8 antibody enables detailed characterization of ZNT8 expression, localization, and immunogenicity in metabolic and autoimmune contexts.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLC30A8 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLC30A8 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLC30A8 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLC30A8 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLC30A8+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047305929069,"sku":"FY12920","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d1892f1a-0dff-4243-b9c2-4ceb7f4787aa.jpg?v=1782237055","url":"https:\/\/www.ebiohippo.com\/products\/slc30a8-antibody-znt8-zinc-transporter-8-bha17135822","provider":"BioHippo","version":"1.0","type":"link"}