{"product_id":"slc39a8-antibody-zip8-solute-carrier-family-39-member-8-bha17135517","title":"SLC39A8 Antibody \/ ZIP8 \/ Solute carrier family 39 member 8","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLC39A8 Antibody \/ ZIP8 \/ Solute carrier family 39 member 8 is a anti-SLC39A8 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLC39A8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSLC39A8 antibody detects Solute carrier family 39 member 8, also called Metal cation symporter ZIP8 and Zrt- and Irt-like protein 8, and a divalent metal ion transporter primarily responsible for manganese and zinc uptake into cells. SLC39A8 is essential for metal ion homeostasis, mitochondrial function, and glycosylation. The SLC39A8 antibody is widely used in biochemistry, metabolism, and neurobiology research to study metal transport, oxidative stress, and enzyme regulation.\u003cbr\u003e\u003cbr\u003eSLC39A8 is encoded by the SLC39A8 gene located on human chromosome 4q24. The protein is approximately 490 amino acids in length and belongs to the ZIP (Zrt\/Irt-like protein) family of metal ion transporters. It localizes to the plasma membrane and mitochondria, where it facilitates cellular uptake of manganese, zinc, iron, and other cations necessary for enzymatic function and metabolic regulation.\u003cbr\u003e\u003cbr\u003eThe SLC39A8 antibody detects a 55 kilodalton band by western blot and reveals plasma membrane and cytoplasmic staining under immunofluorescence. Through regulation of manganese transport, SLC39A8 supports the activity of critical metalloenzymes such as mitochondrial superoxide dismutase and glycosyltransferases. Deficiency of SLC39A8 leads to systemic manganese depletion, mitochondrial dysfunction, and defective glycoprotein synthesis.\u003cbr\u003e\u003cbr\u003eGenetic mutations in SLC39A8 are associated with congenital disorders of glycosylation, intellectual disability, and dystonia. The transporter also influences susceptibility to metabolic syndrome, hypertension, and schizophrenia through its impact on trace element homeostasis and inflammation. Overexpression or mislocalization of SLC39A8 alters cellular redox balance and zinc-dependent signaling pathways.\u003cbr\u003e\u003cbr\u003eBecause of its central role in metal transport and mitochondrial metabolism, SLC39A8 serves as a biomarker for trace element disorders and mitochondrial pathologies.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLC39A8 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLC39A8 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLC39A8 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLC39A8 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLC39A8+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047294296429,"sku":"FY12614","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5f31878d-48b6-46a3-931f-a8dd90f3d8dc.jpg?v=1782237049","url":"https:\/\/www.ebiohippo.com\/products\/slc39a8-antibody-zip8-solute-carrier-family-39-member-8-bha17135517","provider":"BioHippo","version":"1.0","type":"link"}