{"product_id":"slc7a11-antibody-xct-solute-carrier-family-7-member-11-bha17135397","title":"SLC7A11 Antibody \/ XCT \/ Solute carrier family 7 member 11","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLC7A11 Antibody \/ XCT \/ Solute carrier family 7 member 11 is a anti-SLC7A11 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLC7A11\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSLC7A11 antibody detects Solute carrier family 7 member 11, a cystine\/glutamate antiporter subunit that mediates cellular cystine uptake in exchange for intracellular glutamate export. SLC7A11, also known as xCT, forms part of the system Xc- transporter complex, playing an essential role in maintaining redox balance through glutathione synthesis. The SLC7A11 antibody is widely used in cancer, neurobiology, and oxidative stress research to investigate mechanisms of redox regulation and ferroptosis resistance.\u003cbr\u003e\u003cbr\u003eSLC7A11 is encoded by the SLC7A11 gene located on human chromosome 4q28.3. The protein is approximately 55 kilodaltons and partners with the heavy chain subunit SLC3A2 (4F2hc) to form a functional heterodimeric transporter. This complex mediates sodium-independent cystine uptake coupled to glutamate export. Cystine is rapidly reduced intracellularly to cysteine, a rate-limiting precursor for glutathione synthesis, which protects cells from oxidative stress. SLC7A11 activity is therefore tightly linked to redox homeostasis and cellular antioxidant capacity.\u003cbr\u003e\u003cbr\u003eThe SLC7A11 antibody typically detects a 55 kilodalton protein by western blot, with strong expression in the plasma membrane and perinuclear compartments. It is transcriptionally regulated by NRF2 under oxidative stress and suppressed by p53 during stress-induced ferroptosis. Overexpression of SLC7A11 confers resistance to ferroptosis, a form of iron-dependent cell death caused by lipid peroxidation. Conversely, inhibition of SLC7A11 sensitizes cells to oxidative damage and promotes ferroptotic death, making it a key therapeutic target in oncology.\u003cbr\u003e\u003cbr\u003eFunctionally, SLC7A11 expression is elevated in various cancers, including lung, breast, and pancreatic tumors, where it supports tumor growth by enhancing glutathione synthesis and metabolic reprogramming. It is also implicated in neurodegenerative diseases and ischemic injury through its role in glutamate release and excitotoxicity. \u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLC7A11 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLC7A11 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLC7A11 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLC7A11 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLC7A11+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ul","offer_id":53047291281773,"sku":"FY12494","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ceefdad3-7584-499e-8244-3504b5a09a0b.jpg?v=1782237012","url":"https:\/\/www.ebiohippo.com\/products\/slc7a11-antibody-xct-solute-carrier-family-7-member-11-bha17135397","provider":"BioHippo","version":"1.0","type":"link"}