{"product_id":"slc7a14-antibody-solute-carrier-family-7-member-14-bha17135840","title":"SLC7A14 Antibody \/ Solute carrier family 7 member 14","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLC7A14 Antibody \/ Solute carrier family 7 member 14 is a anti-SLC7A14 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Punctate cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLC7A14\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSLC7A14 antibody detects Solute carrier family 7 member 14, a lysosomal cationic amino acid transporter critical for maintaining lysosomal homeostasis and neuronal survival. The UniProt recommended name is Solute carrier family 7 member 14 (SLC7A14), with alternate names cationic amino acid transporter-related protein 1 (CATR1), SLC7A14 protein, and lysosomal arginine transporter. SLC7A14 belongs to the solute carrier (SLC) superfamily of amino acid transporters, specifically the cationic amino acid transporter-like (CAT-like) subgroup.\u003cbr\u003e\u003cbr\u003eFunctionally, SLC7A14 antibody recognizes a multi-pass transmembrane protein localized to the lysosomal membrane, where it facilitates the uptake of arginine and other cationic amino acids from the cytoplasm into the lysosome. This transport is essential for maintaining amino acid balance, lysosomal integrity, and mTOR signaling. SLC7A14 is highly expressed in sensory neurons of the retina and cochlea, and loss of function leads to progressive vision and hearing loss. Mutations in SLC7A14 cause autosomal recessive retinitis pigmentosa and auditory neuropathy, making it a gene of growing clinical significance in neurodegeneration research.\u003cbr\u003e\u003cbr\u003eAt the molecular level, SLC7A14 contains 14 predicted transmembrane helices and shares structural features with other CAT family members but displays lysosome-specific trafficking signals. The transporter's localization depends on interactions with adaptor protein complexes such as AP-3 and lysosomal membrane proteins including LAMP1. SLC7A14 antibody is employed to study neuronal lysosome biology, amino acid metabolism, and neurodegenerative disease models. Studies demonstrate that reduced SLC7A14 impairs lysosomal function, increases oxidative stress, and triggers neuronal apoptosis. Expression analysis shows enrichment in inner hair cells, photoreceptors, and hippocampal neurons, linking it to sensory function and neural plasticity.\u003cbr\u003e\u003cbr\u003eThe SLC7A14 gene is located on chromosome 3q26.2 and encodes a 561-amino acid protein. Beyond sensory tissues, SLC7A14 transcripts have been detected in endocrine cells and fibroblasts, suggesting roles in nutrient sensing and metabolic regulation. Overexpression experiments indicate SLC7A14 contributes to amino acid-regulated mTORC1 activation, coupling lysosomal nutrient availability with cellular growth signals. The SLC7A14 antibody is valuable for immunofluorescence and confocal microscopy to confirm lysosomal localization and evaluate expression changes in disease models.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLC7A14 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLC7A14 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLC7A14 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLC7A14 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLC7A14+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047306518893,"sku":"FY12938","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a4253852-118a-4cd1-b9ed-6709aa300b16.jpg?v=1782237054","url":"https:\/\/www.ebiohippo.com\/products\/slc7a14-antibody-solute-carrier-family-7-member-14-bha17135840","provider":"BioHippo","version":"1.0","type":"link"}