{"product_id":"slco1c1-antibody-solute-carrier-organic-anion-transporter-family-member-1c1-oatp14-bha17135835","title":"SLCO1C1 Antibody \/ Solute carrier organic anion transporter family member 1C1 \/ OATP14","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLCO1C1 Antibody \/ Solute carrier organic anion transporter family member 1C1 \/ OATP14 is a anti-SLCO1C1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLCO1C1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSLCO1C1 antibody detects solute carrier organic anion transporter family member 1C1, also known as OATP14, a transporter responsible for the uptake of thyroid hormones and other organic anions across cellular membranes. The UniProt recommended name is Solute carrier organic anion transporter family member 1C1 (SLCO1C1), with alternate names organic-anion-transporting polypeptide 1C1, OATP-F, OATP14, and OATPF. SLCO1C1 is primarily expressed at the blood-brain barrier and the choroid plexus, where it mediates the high-affinity transport of thyroxine (T4) and reverse triiodothyronine (rT3), supporting central nervous system homeostasis.\u003cbr\u003e\u003cbr\u003eFunctionally, SLCO1C1 antibody targets a transmembrane glycoprotein belonging to the solute carrier (SLC) superfamily, subfamily SLCO, which facilitates sodium-independent transport of amphipathic organic compounds including hormones, bile acids, and drugs. In the brain, SLCO1C1 is essential for delivering thyroid hormones necessary for neuronal differentiation and metabolism. Loss of SLCO1C1 function or genetic variants reduce T4 influx into the brain, contributing to thyroid hormone deficiency and impaired neurological development. Beyond the brain, SLCO1C1 transcripts have been detected in the testis, placenta, and endothelial cells, suggesting broader roles in hormone clearance and intercellular signaling.\u003cbr\u003e\u003cbr\u003eResearchers use SLCO1C1 antibody in western blotting, immunofluorescence, and immunohistochemistry to assess expression at the blood-brain barrier and study its regulation under disease or drug-induced conditions. SLCO1C1 expression is regulated by nuclear receptors such as PXR, LXR, and HNF4alpha, integrating endocrine and metabolic cues. Polymorphisms in SLCO1C1 affect pharmacokinetics of thyroid hormone analogs and certain drugs, making it a pharmacogenomic biomarker for personalized medicine approaches. The protein contains 12 predicted transmembrane domains typical of OATP transporters, with glycosylation sites important for proper folding and localization.\u003cbr\u003e\u003cbr\u003eThe SLCO1C1 gene is located on chromosome 12p12.1 and encodes a protein of about 643 amino acids. It shares structural similarity with other OATP family members such as SLCO1A2, SLCO1B1, and SLCO1B3, but exhibits unique tissue distribution and substrate specificity. Functional studies reveal that SLCO1C1 contributes significantly to the transport of T4 and rT3 across endothelial cells, maintaining thyroid hormone gradients crucial for neuronal activity. Dysfunction in SLCO1C1 expression has been implicated in neurodevelopmental delay, cognitive impairment, and altered drug disposition in the CNS.\u003cbr\u003e\u003cbr\u003eBy enabling precise detection of this transporter, the SLCO1C1 antibody is a critical reagent for understanding thyroid hormone transport, blood-brain barrier permeability, and transporter-mediated drug delivery.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLCO1C1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLCO1C1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLCO1C1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLCO1C1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLCO1C1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047306158445,"sku":"FY12933","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ed14fc63-1227-4936-b08c-14cd28310b89.jpg?v=1782237061","url":"https:\/\/www.ebiohippo.com\/products\/slco1c1-antibody-solute-carrier-organic-anion-transporter-family-member-1c1-oatp14-bha17135835","provider":"BioHippo","version":"1.0","type":"link"}