{"product_id":"slfn12-antibody-schlafen-family-member-12-bha17135802","title":"SLFN12 Antibody \/ Schlafen family member 12","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLFN12 Antibody \/ Schlafen family member 12 is a anti-SLFN12 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLFN12\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSLFN12 antibody detects Schlafen family member 12, a cytoplasmic regulatory protein involved in epithelial differentiation, translational control, and antiviral defense. Encoded by the SLFN12 gene on chromosome 17q12, this member of the Schlafen family functions as a modulator of protein synthesis and cellular differentiation through interactions with the ribosome and mRNA translation machinery. SLFN12 expression is induced by interferon signaling and during epithelial maturation, linking immune regulation with cell differentiation.\u003cbr\u003e\u003cbr\u003eStructurally, SLFN12 is a 578-amino-acid protein of approximately 66 kilodaltons containing an N-terminal Schlafen domain and C-terminal helicase-like motifs that mediate RNA and ribosome binding. Unlike some other Schlafen family members, SLFN12 lacks DNA helicase activity but regulates translation elongation and protein turnover through non-catalytic interactions. It localizes mainly to the cytoplasm and perinuclear region, where it acts as a translational repressor for specific mRNAs involved in proliferation and stress response.\u003cbr\u003e\u003cbr\u003eThe SLFN12 antibody is widely used in immunology, virology, and epithelial biology research to study interferon-stimulated gene expression, translational regulation, and mucosal differentiation. Western blot analysis identifies a 66 kilodalton band corresponding to SLFN12, while immunofluorescence shows cytoplasmic and perinuclear staining in epithelial and immune cells. This antibody supports studies examining the intersection of innate immune signaling, protein translation, and epithelial homeostasis.\u003cbr\u003e\u003cbr\u003eFunctionally, SLFN12 inhibits translation of certain viral and cellular mRNAs, contributing to the antiviral defense mechanisms of interferon-stimulated cells. It also regulates epithelial differentiation in intestinal and airway epithelia by repressing translation of growth-promoting proteins and promoting barrier maturation. Dysregulation of SLFN12 expression is linked to abnormal epithelial remodeling, inflammation, and tumorigenesis. The SLFN12 antibody provides a high-quality tool for exploring Schlafen protein function, immune signaling, and translational control mechanisms.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLFN12 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLFN12 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLFN12 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLFN12 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLFN12+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047305240941,"sku":"FY12900","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f4725d30-a7ba-4637-b320-e85d192bf2cc.jpg?v=1782237058","url":"https:\/\/www.ebiohippo.com\/products\/slfn12-antibody-schlafen-family-member-12-bha17135802","provider":"BioHippo","version":"1.0","type":"link"}