{"product_id":"slfn14-antibody-schlafen-family-member-14-bha17136043","title":"SLFN14 Antibody \/ Schlafen family member 14","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSLFN14 Antibody \/ Schlafen family member 14 is a anti-SLFN14 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SLFN14\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSLFN14 antibody detects Schlafen family member 14, an endoribonuclease that regulates platelet formation, immune function, and mRNA decay. The UniProt recommended name is Schlafen family member 14 (SLFN14). This protein belongs to the Schlafen family, which modulates cell proliferation, differentiation, and antiviral defense through RNA processing and translation control.\u003cbr\u003e\u003cbr\u003eFunctionally, SLFN14 antibody identifies a 505-amino-acid cytoplasmic enzyme that cleaves ribosomal and messenger RNA, regulating protein synthesis and megakaryocyte maturation. SLFN14 is expressed in platelets and hematopoietic cells, where it promotes proper thrombocyte formation and prevents excessive RNA accumulation. It also contributes to innate immune defense by degrading viral RNA.\u003cbr\u003e\u003cbr\u003eThe SLFN14 gene is located on chromosome 17q12 and is primarily expressed in bone marrow, platelets, and immune cells. SLFN14 activity links RNA metabolism with hematopoiesis and antiviral immunity. Its function depends on ATP-binding and nuclease domains that enable targeted RNA degradation.\u003cbr\u003e\u003cbr\u003ePathologically, mutations in SLFN14 cause inherited thrombocytopenia, a bleeding disorder characterized by reduced platelet count and function. These mutations impair endoribonuclease activity, leading to defective megakaryocyte development. Research using SLFN14 antibody supports studies in hematopoiesis, RNA biology, and immune regulation.\u003cbr\u003e\u003cbr\u003eSLFN14 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect RNA-processing enzymes. \u003cbr\u003e\u003cbr\u003eStructurally, Schlafen family member 14 features conserved Schlafen core and nuclease domains that coordinate RNA cleavage and nucleotide binding. This antibody enables exploration of SLFN14's role in platelet formation and RNA turnover.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SLFN14 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SLFN14 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SLFN14 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SLFN14 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SLFN14+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047313924461,"sku":"FY13141","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_64ef1bed-54d3-4977-af93-1a4908f47348.jpg?v=1782237113","url":"https:\/\/www.ebiohippo.com\/products\/slfn14-antibody-schlafen-family-member-14-bha17136043","provider":"BioHippo","version":"1.0","type":"link"}