{"product_id":"slug-antibody-bha17101115","title":"SLUG Antibody","description":"SNAI2\/SLUG is a transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting \u003ca href=\"..\/search_result.php?search_txt=ctbp\"\u003eCTBP1\u003c\/a\u003e and \u003ca href=\"..\/search_result.php?search_txt=hdac1\"\u003eHDAC1\u003c\/a\u003e in breast cells. In epidermal keratinocytes, binds to the E-box in \u003ca href=\"..\/search_result.php?search_txt=itga3\"\u003eITGA3\u003c\/a\u003e promoter and represses its transcription. Involved in the regulation of \u003ca href=\"..\/search_result.php?search_txt=itgb1\"\u003eITGB1\u003c\/a\u003e and \u003ca href=\"..\/search_result.php?search_txt=itgb4\"\u003eITGB4\u003c\/a\u003e expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses \u003ca href=\"..\/search_result.php?search_txt=e-cadherin\"\u003eE-Cadherin\u003c\/a\u003e\/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. [UniProt]\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePredicted species reactivity:\u003c\/strong\u003e Bovine, Mouse, Rat\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53042890342765,"sku":"F47912-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53042972787053,"sku":"F47912-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_65929419-aaf7-49c6-ae5b-89c2771fb883.jpg?v=1771923790","url":"https:\/\/www.ebiohippo.com\/products\/slug-antibody-bha17101115","provider":"BioHippo","version":"1.0","type":"link"}