{"product_id":"smad3-antibody-bha17100576","title":"SMAD3 Antibody","description":"SMAD3 is a receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by \u003ca href=\"..\/search_result.php?search_txt=tgfb\"\u003eTGF-beta\u003c\/a\u003e (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the \u003ca href=\"..\/search_result.php?search_txt=smad3\"\u003eSMAD3\u003c\/a\u003e\/\u003ca href=\"..\/search_result.php?search_txt=smad4\"\u003eSMAD4\u003c\/a\u003e complex, activates transcription. Also can form a SMAD3\/SMAD4\/JUN\/FOS complex at the AP-1\/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF- mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the \u003ca href=\"..\/search_result.php?search_txt=14-3-3\"\u003e14-3-3\u003c\/a\u003e protein YWHAQ which acts as a negative regulator. [UniProt]\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePredicted species reactivity:\u003c\/strong\u003e Mouse, Rat, Pig, Chicken\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53042873598317,"sku":"F43048-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53042955223405,"sku":"F43048-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_af500e2e-b474-4bdb-93a2-4784e8a3457c.jpg?v=1771923701","url":"https:\/\/www.ebiohippo.com\/products\/smad3-antibody-bha17100576","provider":"BioHippo","version":"1.0","type":"link"}