{"product_id":"smc1b-antibody-structural-maintenance-of-chromosomes-protein-1b-bha17135683","title":"SMC1B Antibody \/ Structural maintenance of chromosomes protein 1B","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSMC1B Antibody \/ Structural maintenance of chromosomes protein 1B is a anti-SMC1B Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SMC1B\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSMC1B antibody detects Structural maintenance of chromosomes protein 1B, a cohesin complex component essential for chromosome cohesion during meiosis. Encoded by the SMC1B gene on chromosome 22q13.33, this protein is a meiosis-specific paralog of the somatic cohesin subunit SMC1A. SMC1B forms part of the cohesin ring complex that links sister chromatids and facilitates homologous recombination and synapsis. It ensures accurate chromosome segregation and genomic integrity in germ cells, playing a critical role in gametogenesis and fertility.\u003cbr\u003e\u003cbr\u003eSMC1B forms heterodimers with SMC3 and associates with meiosis-specific cohesin components such as REC8, STAG3, and RAD21L. Together, these proteins establish and maintain cohesion between homologous chromosomes from prophase I until anaphase I, preventing premature separation. SMC1B also contributes to chromatin organization, double-strand break repair, and gene regulation during meiosis. Its expression is restricted mainly to germ cells in the testes and ovaries, though low levels may be detected in certain somatic tissues under specific developmental conditions.\u003cbr\u003e\u003cbr\u003eThe SMC1B antibody is used in cell biology, reproductive, and chromatin research to investigate cohesin complex formation and meiotic chromosome dynamics. Western blot analysis identifies a 145 kilodalton band corresponding to SMC1B, while immunofluorescence reveals chromosomal axis localization in meiotic cells. This antibody supports studies of meiotic cohesion, synaptonemal complex assembly, and chromosomal recombination.\u003cbr\u003e\u003cbr\u003eDeficiency or mutation of SMC1B disrupts chromosome pairing and leads to infertility, meiotic arrest, or aneuploidy. Beyond meiosis, SMC1B may contribute to chromatin architecture and DNA repair in somatic cells. The SMC1B antibody provides a powerful tool for characterizing cohesin-mediated chromosome interactions and meiotic mechanisms.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SMC1B - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SMC1B - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SMC1B - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SMC1B - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SMC1B+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047300194669,"sku":"FY12780","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b24d8fbc-4172-475a-9233-cf14c0d820b0.jpg?v=1782237050","url":"https:\/\/www.ebiohippo.com\/products\/smc1b-antibody-structural-maintenance-of-chromosomes-protein-1b-bha17135683","provider":"BioHippo","version":"1.0","type":"link"}