{"product_id":"sncb-antibody-beta-synuclein-bha17135418","title":"SNCB Antibody \/ Beta Synuclein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSNCB Antibody \/ Beta Synuclein is a anti-SNCB Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) with listed reactivity in Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SNCB\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IF\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSNCB antibody detects Beta-synuclein, a presynaptic neuronal protein belonging to the synuclein family, which also includes alpha- and gamma-synuclein. Beta-synuclein is abundant in the brain, particularly in synaptic terminals, and functions in synaptic vesicle regulation, neurotransmitter release, and neuronal plasticity. The SNCB antibody is used in neuroscience, neurodegeneration, and synaptic biology research.\u003cbr\u003e\u003cbr\u003eBeta-synuclein is encoded by the SNCB gene located on human chromosome 5q35.2. The protein is approximately 134 amino acids in length and intrinsically disordered, allowing it to adopt multiple conformations upon membrane binding. Unlike alpha-synuclein, Beta-synuclein lacks the hydrophobic non-amyloid component domain that promotes aggregation, and therefore is considered non-amyloidogenic under physiological conditions. This makes it an important natural modulator of synuclein aggregation balance.\u003cbr\u003e\u003cbr\u003eThe SNCB antibody detects a 14-20 kilodalton protein by western blot and shows intense staining in synaptic regions under immunohistochemistry. Beta-synuclein associates with synaptic vesicles through lipid interactions and regulates neurotransmitter release by modulating SNARE complex dynamics. It may act as a molecular chaperone preventing pathological alpha-synuclein aggregation. Reduced expression or mutations in SNCB have been linked to dementia with Lewy bodies and Parkinson-like neurodegenerative disorders.\u003cbr\u003e\u003cbr\u003eBeta-synuclein also influences calcium signaling, vesicle recycling, and synaptic stability. Its expression is developmentally regulated, increasing as neurons mature. Under oxidative stress or protein misfolding conditions, Beta-synuclein may acquire toxic gain-of-function properties, forming soluble oligomers that disrupt vesicular trafficking. Recent evidence indicates that it may modulate dopaminergic neuron vulnerability through redox regulation and mitochondrial interactions.\u003cbr\u003e\u003cbr\u003eBeyond neurodegeneration, Beta-synuclein is expressed in certain endocrine and peripheral tissues, where it regulates vesicle release. It has potential as a biomarker for neurological diseases and as a therapeutic target to stabilize alpha-synuclein homeostasis.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SNCB - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SNCB - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SNCB - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SNCB - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SNCB+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047290659181,"sku":"FY12515","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_fdadf837-d40f-4b59-ba79-ca4d3cfc6240.jpg?v=1782237016","url":"https:\/\/www.ebiohippo.com\/products\/sncb-antibody-beta-synuclein-bha17135418","provider":"BioHippo","version":"1.0","type":"link"}