{"product_id":"snrk-antibody-snf-related-serine-threonine-protein-kinase-bha17136221","title":"SNRK Antibody \/ SNF-related serine\/threonine-protein kinase","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSNRK Antibody \/ SNF-related serine\/threonine-protein kinase is a anti-SNRK Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SNRK\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSNRK antibody detects SNF-related serine\/threonine-protein kinase, a cytoplasmic and nuclear kinase encoded by the SNRK gene on chromosome 3q25.1. SNRK belongs to the AMP-activated protein kinase (AMPK)-related kinase family and functions as an energy sensor that regulates metabolism, inflammation, and cellular stress responses. The SNRK protein localizes to both cytoplasm and nucleus, where it phosphorylates substrates involved in energy metabolism, autophagy, and cardiac development. Like other AMPK family kinases, SNRK responds to changes in cellular ATP levels, linking nutrient availability to metabolic adaptation.\u003cbr\u003e\u003cbr\u003eSNRK antibody identifies a kinase containing an N-terminal catalytic domain with the conserved activation loop threonine residue, followed by a unique C-terminal regulatory region that mediates protein-protein interactions. Activation of SNRK occurs via phosphorylation by upstream kinases such as LKB1. Once activated, SNRK phosphorylates downstream targets that regulate glucose uptake, fatty acid oxidation, and mitochondrial function. It plays a key role in maintaining cellular energy homeostasis under metabolic stress.\u003cbr\u003e\u003cbr\u003eIn cardiac tissue, SNRK supports myocardial energy efficiency and contractile function by modulating lipid metabolism and mitochondrial biogenesis. Loss of SNRK impairs mitochondrial respiration and increases susceptibility to metabolic disorders. In neurons, SNRK contributes to synaptic vesicle trafficking and axonal growth through phosphorylation of cytoskeletal and vesicle-associated proteins. Additionally, SNRK modulates inflammatory pathways by phosphorylating NF-kappaB regulators and promoting macrophage polarization toward an anti-inflammatory phenotype.\u003cbr\u003e\u003cbr\u003ePathway involvement of SNRK includes the AMPK signaling network, where it acts downstream of metabolic stress sensors to control autophagy, oxidative metabolism, and lipid catabolism. The kinase also participates in developmental signaling related to angiogenesis and cardiogenesis. Studies have shown that SNRK expression increases during fasting or hypoxia, supporting its role in adaptive metabolic regulation. Structurally, SNRK shares homology with other AMPK family kinases such as MARK2 and NUAK1, containing conserved ATP-binding and activation loop motifs.\u003cbr\u003e\u003cbr\u003eClinically, alterations in SNRK expression have been associated with obesity, insulin resistance, and heart disease. In the nervous system, SNRK dysregulation may contribute to neuroinflammation and neurodegeneration. Genome-wide association studies have linked SNRK variants to lipid metabolism disorders and coronary artery disease risk. The kinase's regulatory control of energy metabolism and inflammatory responses makes it a promising therapeutic target for metabolic and cardiovascular disease research.\u003cbr\u003e\u003cbr\u003eImmunohistochemical staining using SNRK antibody shows cytoplasmic and nuclear localization in cardiac myocytes, neurons, and hepatocytes. The SNRK antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SNRK - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SNRK - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SNRK - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SNRK - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SNRK+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047322673517,"sku":"FY13319","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_61525c2f-d10f-406b-910a-d78681f16551.jpg?v=1782237101","url":"https:\/\/www.ebiohippo.com\/products\/snrk-antibody-snf-related-serine-threonine-protein-kinase-bha17136221","provider":"BioHippo","version":"1.0","type":"link"}