{"product_id":"snta1-antibody-alpha-1-syntrophin-bha17135825","title":"SNTA1 Antibody \/ Alpha-1-Syntrophin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSNTA1 Antibody \/ Alpha-1-Syntrophin is a anti-SNTA1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SNTA1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSNTA1 antibody detects Alpha-1-syntrophin, a cytoskeletal adaptor protein that organizes signaling complexes at the plasma membrane, particularly in muscle and neuronal tissues. Encoded by the SNTA1 gene on chromosome 20q11.2, this protein belongs to the syntrophin family of PDZ domain-containing scaffold proteins that associate with dystrophin and dystrobrevin to form part of the dystrophin-associated protein complex (DAPC). Alpha-1-syntrophin facilitates communication between membrane channels, receptors, and intracellular signaling proteins, contributing to cellular structural integrity and signaling regulation.\u003cbr\u003e\u003cbr\u003eStructurally, Alpha-1-syntrophin is a 505-amino-acid cytoplasmic protein of approximately 55 kilodaltons containing multiple modular domains, including a pleckstrin homology (PH) domain, a PDZ domain, and a C-terminal syntrophin unique (SU) region. These domains mediate interactions with membrane proteins such as neuronal nitric oxide synthase (nNOS), ion channels, and cytoskeletal elements. The protein localizes to the sarcolemma in muscle cells and to synaptic and submembranous regions in neurons.\u003cbr\u003e\u003cbr\u003eThe SNTA1 antibody is widely used in muscle biology, neuroscience, and cardiovascular research to study membrane organization, signal transduction, and cytoskeletal dynamics. Western blot analysis detects a 55 kilodalton band corresponding to Alpha-1-syntrophin, while immunofluorescence reveals membrane-associated and cytoplasmic staining patterns consistent with its adaptor function. This antibody provides a reliable tool for examining the molecular architecture of membrane-associated signaling complexes.\u003cbr\u003e\u003cbr\u003eFunctionally, SNTA1 regulates nitric oxide signaling, calcium homeostasis, and ion channel activity by linking nNOS and other signaling proteins to the DAPC. Mutations in SNTA1 have been associated with long QT syndrome and cardiac arrhythmias, suggesting a role in maintaining proper electrical signaling in cardiomyocytes. Alpha-1-syntrophin also influences cellular migration and polarization by anchoring signaling complexes at specific membrane domains. The SNTA1 antibody supports research into cytoskeletal organization, membrane signaling, and neuromuscular disease.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SNTA1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SNTA1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SNTA1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SNTA1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SNTA1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047306027373,"sku":"FY12923","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9a309403-1182-4491-8349-4d34c1fbd30e.jpg?v=1782237050","url":"https:\/\/www.ebiohippo.com\/products\/snta1-antibody-alpha-1-syntrophin-bha17135825","provider":"BioHippo","version":"1.0","type":"link"}