{"product_id":"sntb1-antibody-beta-1-syntrophin-bha17135713","title":"SNTB1 Antibody \/ Beta-1-Syntrophin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSNTB1 Antibody \/ Beta-1-Syntrophin is a anti-SNTB1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SNTB1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSNTB1 antibody detects Beta-1-syntrophin, a cytoskeletal adaptor protein involved in signal transduction, membrane organization, and muscle integrity. Encoded by the SNTB1 gene on chromosome 8q23.1, this protein belongs to the syntrophin family, which binds to dystrophin and associated glycoprotein complexes at the sarcolemma. SNTB1 links signaling molecules to the cytoskeleton, coordinating ion channel localization, receptor clustering, and intracellular signaling in muscle and neuronal tissues.\u003cbr\u003e\u003cbr\u003eStructurally, SNTB1 contains PDZ, PH, and SU domains that mediate interactions with ion channels, kinases, and membrane receptors. It associates with the dystrophin complex through its PH domain and serves as a scaffold for signaling proteins such as neuronal nitric oxide synthase (nNOS) and voltage-gated sodium channels. By organizing these proteins at the plasma membrane, SNTB1 maintains muscle membrane stability and signal transduction efficiency.\u003cbr\u003e\u003cbr\u003eThe SNTB1 antibody is used in muscle biology, neuroscience, and membrane signaling research to study the dystrophin-associated complex and its role in muscular and neurological disorders. Western blot analysis identifies a 60 kilodalton band corresponding to SNTB1, while immunofluorescence reveals sarcolemmal and cytoplasmic staining in muscle fibers and neurons. This antibody provides a critical tool for exploring membrane-associated scaffolding and signaling mechanisms.\u003cbr\u003e\u003cbr\u003eMutations or altered expression of syntrophin family members, including SNTB1, contribute to muscular dystrophy, channelopathies, and synaptic dysfunction. SNTB1 also participates in signaling pathways regulating calcium homeostasis and cytoskeletal remodeling. The SNTB1 antibody supports research into these pathways and their implications in neuromuscular and cardiovascular diseases.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SNTB1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SNTB1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SNTB1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SNTB1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SNTB1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047302390125,"sku":"FY12811","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_da1950aa-70cb-4a35-a701-53908a72513d.jpg?v=1782237038","url":"https:\/\/www.ebiohippo.com\/products\/sntb1-antibody-beta-1-syntrophin-bha17135713","provider":"BioHippo","version":"1.0","type":"link"}