{"product_id":"snx4-antibody-sorting-nexin-4-bha17135419","title":"SNX4 Antibody \/ Sorting nexin 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSNX4 Antibody \/ Sorting nexin 4 is a anti-SNX4 Rabbit antibody Recombinant Rabbit Monoclonal clone 30S54 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunoprecipitation (IP) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SNX4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30S54, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSNX4 antibody detects sorting nexin 4, a member of the sorting nexin family encoded by the SNX4 gene. Sorting nexins are characterized by the presence of a phox homology domain that binds phosphoinositides, enabling association with endosomal membranes. SNX4 is primarily involved in endosomal trafficking, cargo sorting, and membrane remodeling. By directing proteins to recycling or degradative pathways, SNX4 maintains cellular homeostasis and regulates receptor signaling.\u003cbr\u003e\u003cbr\u003eSNX4 antibody is widely applied in studies of membrane trafficking, endocytosis, and signal transduction. Sorting nexin 4 is part of the retromer independent recycling pathway and contributes to the trafficking of proteins such as the transferrin receptor. Disruption of SNX4 function impairs endosomal sorting and alters nutrient uptake, receptor turnover, and intracellular signaling dynamics. By detecting SNX4, researchers can explore how sorting nexins control endosomal recycling and cell surface composition.\u003cbr\u003e\u003cbr\u003eIn western blot assays, SNX4 antibody detects protein bands of the expected size in cell and tissue extracts. Immunohistochemistry highlights expression in epithelial and neuronal tissues, while immunofluorescence maps SNX4 distribution on endosomal membranes. These methods support detailed analysis of endosomal dynamics.\u003cbr\u003e\u003cbr\u003eSNX4 has been implicated in neurodegenerative disease and cancer. Altered expression affects autophagy, mitochondrial function, and neuronal survival. In oncology, abnormal SNX4 activity influences growth factor receptor trafficking and signaling, potentially affecting tumor progression. By applying SNX4 antibody, scientists can investigate how sorting nexin mediated trafficking pathways contribute to both normal physiology and disease.\u003cbr\u003e\u003cbr\u003eSNX4 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SNX4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SNX4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SNX4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SNX4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SNX4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047290823021,"sku":"FY12516","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c48b2129-9e74-4a86-8317-300e6e082f33.jpg?v=1772019302","url":"https:\/\/www.ebiohippo.com\/products\/snx4-antibody-sorting-nexin-4-bha17135419","provider":"BioHippo","version":"1.0","type":"link"}