{"product_id":"soat1-antibody-sterol-o-acyltransferase-1-bha17135895","title":"SOAT1 Antibody \/ Sterol O-acyltransferase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSOAT1 Antibody \/ Sterol O-acyltransferase 1 is a anti-SOAT1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm (ER).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SOAT1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSOAT1 antibody detects Sterol O-acyltransferase 1, an integral endoplasmic reticulum enzyme responsible for the esterification of cholesterol to form cholesterol esters. The UniProt recommended name is Sterol O-acyltransferase 1 (SOAT1), also known as Acyl-CoA:cholesterol acyltransferase 1 (ACAT1). This enzyme plays a central role in intracellular cholesterol homeostasis, lipid storage, and steroidogenesis.\u003cbr\u003e\u003cbr\u003eFunctionally, SOAT1 antibody identifies a 550-amino-acid multi-pass membrane enzyme that catalyzes the formation of cholesterol esters by transferring fatty acyl groups from acyl-CoA to the hydroxyl group of cholesterol. These neutral esters are stored in cytoplasmic lipid droplets, buffering free cholesterol concentrations within membranes. SOAT1 activity is critical for maintaining cellular lipid balance and protecting against cholesterol-induced cytotoxicity.\u003cbr\u003e\u003cbr\u003eThe SOAT1 gene is located on chromosome 1q25.2 and encodes a protein embedded in the endoplasmic reticulum membrane. It operates as a key metabolic switch regulating cholesterol storage and membrane composition. In macrophages, SOAT1 converts excess cholesterol into cholesteryl esters, preventing foam cell formation and atherogenesis. In steroidogenic tissues, it contributes to the availability of cholesterol precursors for hormone synthesis. Dysregulation of SOAT1 disrupts lipid homeostasis and is implicated in metabolic disorders, neurodegeneration, and cardiovascular disease.\u003cbr\u003e\u003cbr\u003eSOAT1 functions alongside SOAT2, which is primarily expressed in the liver and intestine, while SOAT1 is ubiquitously expressed in peripheral tissues. Its activity is regulated by intracellular cholesterol levels, oxysterols, and acyl-CoA availability. Pharmacological inhibition of SOAT1 has been explored as a strategy to reduce atherosclerotic plaque formation and neurotoxic cholesterol accumulation in Alzheimer's disease.\u003cbr\u003e\u003cbr\u003eSOAT1 antibody is widely used in lipid metabolism, cardiovascular, and neurobiology research. It is suitable for immunoblotting, immunofluorescence, and enzyme localization studies to evaluate intracellular cholesterol esterification. This antibody enables the investigation of lipid droplet formation, cholesterol trafficking, and sterol regulatory pathways. In metabolic studies, SOAT1 serves as a marker of intracellular cholesterol storage and lipid imbalance.\u003cbr\u003e\u003cbr\u003eStructurally, SOAT1 is an endoplasmic reticulum membrane protein containing multiple transmembrane domains and conserved histidine residues essential for catalytic function. The enzyme operates as a homotetramer, with each subunit contributing to the catalytic center.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SOAT1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SOAT1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SOAT1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SOAT1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SOAT1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047309009261,"sku":"FY12993","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_18e453e9-47b4-4486-b7f4-3d97963cf647.jpg?v=1772019415","url":"https:\/\/www.ebiohippo.com\/products\/soat1-antibody-sterol-o-acyltransferase-1-bha17135895","provider":"BioHippo","version":"1.0","type":"link"}