{"product_id":"sod1-edi-antibody-bha11907450","title":"SOD1 (EDI) Antibody","description":"\u003cp\u003eSuperoxide dismutase 1 (SOD1) is a cytosolic antioxidant enzyme that catalyzes the dismutation of superoxide radicals (O₂⁻) into hydrogen peroxide (H₂O₂) and molecular oxygen (O₂), playing a vital role in cellular redox homeostasis. Structurally, SOD1 is a 32 kDa homodimer, with each 16 kDa subunit stabilized by copper and zinc ions, an intra-subunit disulfide bridge, and a tightly packed β-barrel fold.\u003c\/p\u003e\n\n\u003cp\u003eIn neurodegenerative disease research—particularly amyotrophic lateral sclerosis (ALS)—SOD1 misfolding and aggregation are key pathological features. One critical conformational change involves the exposure of the dimer interface (EDI), a normally buried region essential for SOD1 stability and enzymatic function. This structural disruption is associated with toxic gain-of-function mechanisms and neuronal degeneration.\u003c\/p\u003e\n\n\u003cp\u003eConformation-specific antibodies such as SOD1 (EDI) are designed to selectively recognize this exposed dimer interface, enabling researchers to detect early misfolding events in ALS-affected tissues. When used in combination with antibodies like SOD1 (UβB) (catalog# SPC-205), which targets the unfolded β-barrel region, these tools provide a powerful means of mapping SOD1 conformational states and tracking disease progression.\u003c\/p\u003e\n\n\u003cp\u003eTargeting the exposed dimer interface of SOD1 offers a promising strategy for understanding ALS pathogenesis and developing precision diagnostics and therapeutics in neurodegenerative disease research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040793878893,"sku":"SPC-206D","price":312.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040877961581,"sku":"SPC-206D-A390","price":367.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040877994349,"sku":"SPC-206D-A488","price":366.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040878027117,"sku":"SPC-206D-A594","price":366.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040878059885,"sku":"SPC-206D-APC","price":365.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040878092653,"sku":"SPC-206D-BI","price":361.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040878125421,"sku":"SPC-206D-FITC","price":357.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040878158189,"sku":"SPC-206D-HRP","price":352.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040878190957,"sku":"SPC-206D-PCP","price":365.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040878223725,"sku":"SPC-206D-RPE","price":362.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040878256493,"sku":"SPC-206S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPC-206-SOD1-EDI-Antibody-WB-Mouse-Lung-1.png?v=1771832156","url":"https:\/\/www.ebiohippo.com\/products\/sod1-edi-antibody-bha11907450","provider":"BioHippo","version":"1.0","type":"link"}