{"product_id":"sod1-ubetab-antibody-bha11907431","title":"SOD1 (UbetaB) Antibody","description":"\u003cp\u003eSuperoxide dismutase 1 (SOD1) is a copper- and zinc-binding antioxidant enzyme that catalyzes the dismutation of superoxide radicals (O₂⁻) into hydrogen peroxide (H₂O₂) and molecular oxygen (O₂), thereby mitigating oxidative stress in the cytoplasm. Structurally, SOD1 functions as a 32 kDa homodimer, with each 16 kDa subunit stabilized by an intra-subunit disulfide bond and a β-barrel fold critical for its enzymatic activity and structural integrity.\u003c\/p\u003e\n\n\u003cp\u003eIn neurodegenerative disease research—particularly amyotrophic lateral sclerosis (ALS)—SOD1 has emerged as a central player. Mutations in the SOD1 gene can lead to protein misfolding, aggregation, and toxic gain-of-function effects. A key pathological hallmark involves the exposure of normally buried regions of the β-barrel, including the unfolded β-barrel domain, which is implicated in early misfolding events.\u003c\/p\u003e\n\n\u003cp\u003eConformation-specific antibodies such as Anti-SOD1 (UbetaB), which selectively binds the unfolded β-barrel region, are powerful tools for detecting misfolded SOD1 in affected tissues. When used alongside antibodies like Anti-SOD1 (EDI) (catalog# SPC-206), which targets the exposed dimer interface, researchers can map conformational states of SOD1 and track disease progression at the molecular level.\u003c\/p\u003e\n\n\u003cp\u003eUnderstanding and detecting these structural transitions in SOD1 is essential for advancing ALS diagnostics and developing targeted therapeutics in neurodegenerative disease research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040793977197,"sku":"SPC-205D","price":312.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040871735661,"sku":"SPC-205D-A390","price":367.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040871768429,"sku":"SPC-205D-A488","price":366.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040871801197,"sku":"SPC-205D-A594","price":366.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040871833965,"sku":"SPC-205D-APC","price":365.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040871866733,"sku":"SPC-205D-BI","price":361.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040871899501,"sku":"SPC-205D-FITC","price":357.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040871932269,"sku":"SPC-205D-HRP","price":352.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040871965037,"sku":"SPC-205D-PCP","price":365.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040871997805,"sku":"SPC-205D-RPE","price":362.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040872030573,"sku":"SPC-205S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPC-205_SOD1-UBB_Antibody_ICC-IF_Human_HeLa-Cells_100x_Composite.png?v=1771832161","url":"https:\/\/www.ebiohippo.com\/products\/sod1-ubetab-antibody-bha11907431","provider":"BioHippo","version":"1.0","type":"link"}