{"product_id":"sod2-mn-antibody-bha11906503","title":"SOD2 (Mn) Antibody","description":"\u003cp\u003eSuperoxide dismutase 2 (SOD2), a manganese-dependent enzyme localized in the mitochondrial matrix, is a critical component of the cellular antioxidant defense system. It catalyzes the dismutation of superoxide radicals (O₂⁻), a byproduct of mitochondrial respiration, into hydrogen peroxide (H₂O₂) and molecular oxygen (O₂). This reaction is essential for mitigating oxidative stress, particularly in neurons, which are highly susceptible to mitochondrial dysfunction and reactive oxygen species (ROS) accumulation.\u003c\/p\u003e\n\n\u003cp\u003eAmong the three mammalian SOD isoforms—SOD1 (Cu\/Zn, cytosolic), SOD2 (Mn, mitochondrial), and SOD3 (Cu\/Zn, extracellular)—SOD2 is uniquely positioned to protect mitochondrial integrity. Its tetrameric structure and localization enable it to neutralize ROS at their primary source, making it a focal point in studies of neurodegenerative diseases such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis (ALS).\u003c\/p\u003e\n\n\u003cp\u003eDeficiencies or mutations in SOD2 have been linked to increased oxidative damage, mitochondrial impairment, and neuronal cell death. As a result, SOD2 is not only a biomarker of oxidative stress but also a promising therapeutic target in neuroscience. Enhancing SOD2 activity or expression is a growing area of interest in the development of neuroprotective strategies.\u003c\/p\u003e\n\n\u003cp\u003eUnderstanding the role of SOD2 in redox homeostasis is essential for advancing treatments for neurodegenerative disorders and improving mitochondrial health in aging and disease.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040793157997,"sku":"SPC-117D","price":352.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040865673581,"sku":"SPC-117D-A390","price":407.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040865706349,"sku":"SPC-117D-A488","price":406.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040865739117,"sku":"SPC-117D-A594","price":406.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040865771885,"sku":"SPC-117D-APC","price":405.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040865804653,"sku":"SPC-117D-BI","price":402.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040865837421,"sku":"SPC-117D-FITC","price":397.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040865870189,"sku":"SPC-117D-HRP","price":393.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040865902957,"sku":"SPC-117D-PCP","price":405.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040865935725,"sku":"SPC-117D-RPE","price":403.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040865968493,"sku":"SPC-117S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPC-117_SOD-Mn_Antibody_ICC-IF_Human_HeLa-Cells_100x_Composite.png?v=1771832156","url":"https:\/\/www.ebiohippo.com\/products\/sod2-mn-antibody-bha11906503","provider":"BioHippo","version":"1.0","type":"link"}