{"product_id":"sod3-ec-antibody-bha11901036","title":"SOD3 (EC) Antibody","description":"\u003cp\u003eSuperoxide dismutases (SODs) are essential antioxidant enzymes that protect cells from oxidative stress by catalyzing the dismutation of superoxide radicals (O₂⁻) into molecular oxygen (O₂) and hydrogen peroxide (H₂O₂), which are further detoxified by catalase and glutathione peroxidase. Among the three mammalian isoforms—SOD1 (cytoplasmic), SOD2 (mitochondrial), and SOD3 (extracellular)—SOD3 (extracellular superoxide dismutase, EC-SOD) plays a unique and increasingly recognized role in the central nervous system (CNS).\u003c\/p\u003e\n\n\u003cp\u003eSOD3 is a copper- and zinc-containing homotetramer (~30 kDa) localized exclusively in the extracellular matrix, where it binds to heparan sulfate proteoglycans. This localization enables SOD3 to modulate redox signaling and protect neurons and glial cells from extracellular oxidative insults—key contributors to neuroinflammation and neurodegeneration.\u003c\/p\u003e\n\n\u003cp\u003eEmerging evidence links dysregulation of SOD3 expression and activity to the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). Its extracellular positioning makes SOD3 a promising biomarker and therapeutic target for modulating oxidative stress in the brain.\u003c\/p\u003e\n\n\u003cp\u003eUnderstanding the distinct biochemical properties and neuroprotective functions of SOD3 is critical for advancing antioxidant-based strategies in neuroscience and neurodegenerative disease research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040789094765,"sku":"SMC-167D","price":329.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040840147309,"sku":"SMC-167D-A390","price":385.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040840180077,"sku":"SMC-167D-A488","price":384.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040840212845,"sku":"SMC-167D-A594","price":384.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040840245613,"sku":"SMC-167D-APC","price":383.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040840278381,"sku":"SMC-167D-BI","price":379.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040840311149,"sku":"SMC-167D-FITC","price":374.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040840343917,"sku":"SMC-167D-HRP","price":369.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040840376685,"sku":"SMC-167D-PCP","price":383.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040840409453,"sku":"SMC-167D-RPE","price":380.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040840442221,"sku":"SMC-167S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-167_SOD3_Antibody_4GG11G6_ICC-IF_Human_cartilage_1.png?v=1771832137","url":"https:\/\/www.ebiohippo.com\/products\/sod3-ec-antibody-bha11901036","provider":"BioHippo","version":"1.0","type":"link"}