{"product_id":"sort1-antibody-sortilin-bha17136306","title":"SORT1 Antibody \/ Sortilin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSORT1 Antibody \/ Sortilin is a anti-SORT1 Rabbit antibody Recombinant Rabbit Monoclonal clone 17S35 supplied in Purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SORT1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 17S35, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSortilin (SORT1) is a type I transmembrane receptor belonging to the vacuolar protein sorting 10 (VPS10) domain receptor family. It is involved in intracellular protein trafficking, endocytosis, and sorting of a variety of ligands, including neurotrophins, lipoproteins, and enzymes. SORT1 plays an important role in neuronal viability, lipid metabolism, and protein transport between the Golgi apparatus and endosomes.    \u003cp\u003eAltered expression or function of SORT1 has been associated with neurodegenerative disorders, cardiovascular disease, and lipid metabolism abnormalities. Research has linked SORT1 to regulation of low-density lipoprotein (LDL) cholesterol levels and to processes that influence neuronal growth and survival. Understanding SORT1’s biological roles can provide insights into both neurological function and metabolic health. \u003c\/p\u003e\n\u003cp\u003eUsing a high-quality SORT1 antibody enables reliable detection in applications such as western blot, immunohistochemistry, and immunofluorescence. A SORT1 antibody from\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SORT1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SORT1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SORT1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SORT1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SORT1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047325032813,"sku":"RQ8887","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_4c6a5d5e-5dba-410c-b7a8-adfc4313256d.jpg?v=1772019441","url":"https:\/\/www.ebiohippo.com\/products\/sort1-antibody-sortilin-bha17136306","provider":"BioHippo","version":"1.0","type":"link"}