{"product_id":"sox9-antibody-sry-box-transcription-factor-9-bha17136082","title":"SOX9 Antibody \/ SRY-box transcription factor 9","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSOX9 Antibody \/ SRY-box transcription factor 9 is a anti-SOX9 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SOX9\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSOX9 antibody detects SRY-box transcription factor 9, a transcriptional regulator that controls chondrogenesis, sex determination, and stem cell maintenance. The UniProt recommended name is SRY-box transcription factor 9 (SOX9). This protein belongs to the SOX (SRY-related HMG-box) family of transcription factors, characterized by a high-mobility group DNA-binding domain that recognizes specific enhancer sequences.\u003cbr\u003e\u003cbr\u003eFunctionally, SOX9 antibody identifies a 509-amino-acid nuclear protein that binds to promoter and enhancer regions of cartilage-specific genes such as COL2A1 and ACAN. SOX9 forms dimers through its HMG domain and recruits transcriptional coactivators to drive cartilage matrix production and skeletal formation. It also plays roles in sex differentiation by activating AMH (anti-M�llerian hormone) transcription during gonadal development.\u003cbr\u003e\u003cbr\u003eThe SOX9 gene is located on chromosome 17q24.3 and is expressed in developing cartilage, gonads, and neural crest-derived tissues. SOX9 is a master regulator of chondrocyte differentiation and is essential for maintaining progenitor cell identity in multiple lineages.\u003cbr\u003e\u003cbr\u003ePathologically, mutations or haploinsufficiency of SOX9 cause campomelic dysplasia, a severe skeletal malformation syndrome with sex reversal. Aberrant SOX9 expression also contributes to cancer progression and tissue fibrosis. Research using SOX9 antibody supports studies in developmental biology, transcription regulation, and regenerative medicine.\u003cbr\u003e\u003cbr\u003eSOX9 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect transcription factors involved in chondrogenesis and lineage specification. \u003cbr\u003e\u003cbr\u003eStructurally, SRY-box transcription factor 9 contains an HMG DNA-binding domain and transactivation regions that mediate chromatin remodeling and transcriptional activation. This antibody supports detailed analysis of SOX9's regulatory mechanisms in development and disease.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SOX9 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SOX9 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SOX9 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SOX9 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SOX9+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047318118765,"sku":"FY13180","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c06ee2d4-b0ed-4186-98f2-1cf279495cd3.jpg?v=1782237068","url":"https:\/\/www.ebiohippo.com\/products\/sox9-antibody-sry-box-transcription-factor-9-bha17136082","provider":"BioHippo","version":"1.0","type":"link"}