{"product_id":"spsb2-antibody-spla-ryanodine-receptor-domain-and-socs-box-containing-protein-2-bha17135972","title":"SPSB2 Antibody \/ SplA\/Ryanodine receptor domain and SOCS box containing protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSPSB2 Antibody \/ SplA\/Ryanodine receptor domain and SOCS box containing protein 2 is a anti-SPSB2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SPSB2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSPSB2 antibody detects SplA\/Ryanodine receptor domain and SOCS box containing protein 2, an adaptor molecule involved in ubiquitin-mediated proteasomal degradation. The UniProt recommended name is SplA\/Ryanodine receptor domain and SOCS box containing protein 2 (SPSB2). This cytoplasmic protein interacts with substrate proteins through its SPRY domain and recruits E3 ubiquitin ligase complexes via its SOCS box, promoting targeted protein turnover.\u003cbr\u003e\u003cbr\u003eFunctionally, SPSB2 antibody identifies a 293-amino-acid protein that regulates signaling through inducible nitric oxide synthase (iNOS), erythropoietin, and other cytokine-related pathways. SPSB2 binds iNOS, targeting it for proteasomal degradation, thereby controlling nitric oxide production and inflammatory responses. Through this mechanism, SPSB2 contributes to feedback inhibition in immune signaling and maintains cellular redox balance.\u003cbr\u003e\u003cbr\u003eThe SPSB2 gene is located on chromosome 12q24.31 and encodes a member of the SPSB family, which includes SPSB1, SPSB3, and SPSB4. Each family member functions as an adaptor in ubiquitin ligase complexes, characterized by their conserved SPRY and SOCS domains. SPSB2 expression is high in macrophages, spleen, and liver, reflecting its role in immune regulation and metabolic processes.\u003cbr\u003e\u003cbr\u003ePathologically, dysregulated SPSB2 activity affects nitric oxide signaling, contributing to inflammatory disorders, cancer progression, and metabolic stress. By promoting degradation of iNOS, SPSB2 helps terminate inflammatory responses and prevent tissue damage. Reduced SPSB2 levels may prolong nitric oxide signaling, leading to oxidative stress or chronic inflammation.\u003cbr\u003e\u003cbr\u003eSPSB2 antibody is suitable for western blotting, immunohistochemistry, and immunoprecipitation to study protein degradation mechanisms, immune signaling, and nitric oxide regulation. \u003cbr\u003e\u003cbr\u003eStructurally, SPSB2 contains an N-terminal SPRY domain mediating substrate recognition and a C-terminal SOCS box that binds elongin B\/C, Cullin 5, and Rbx2 to assemble an E3 ligase complex. This modular configuration enables selective targeting of regulatory proteins for degradation, linking SPSB2 to diverse cellular pathways governing inflammation and metabolism.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SPSB2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SPSB2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SPSB2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SPSB2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SPSB2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047311073645,"sku":"FY13070","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_fe894d31-2c2f-4628-b27f-8bf5c5e8ab6c.jpg?v=1782237085","url":"https:\/\/www.ebiohippo.com\/products\/spsb2-antibody-spla-ryanodine-receptor-domain-and-socs-box-containing-protein-2-bha17135972","provider":"BioHippo","version":"1.0","type":"link"}