{"product_id":"spy2-rabbit-pab-bha15210941","title":"SPY2 rabbit pAb","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc ul{margin:0 0 12px;padding-left:22px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eThis gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor\/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul\u003c\/p\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003ePolyclonal Rabbit Antibody\u003c\/span\u003e\n\n\u003ch2\u003eValidated Applications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eApplication\u003c\/th\u003e\n\u003cth\u003eRecommended Dilution\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eWestern Blot\u003c\/td\u003e\n\u003ctd\u003eRefer to datasheet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eELISA\u003c\/td\u003e\n\u003ctd\u003eRefer to datasheet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch2\u003eImmunogen \u0026amp; Specificity\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubcellular Localization:\u003c\/strong\u003e Cytoplasm, cytoskeleton . Cell projection, ruffle membrane . Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor). .\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUniProt\/Swiss-Prot:\u003c\/strong\u003e \u003ca href=\"https:\/\/www.uniprot.org\/uniprot\/O43597\" target=\"_blank\"\u003eO43597\u003c\/a\u003e\u003c\/p\u003e\n\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eHost Species\u003c\/th\u003e\n\u003ctd\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eClonality\u003c\/th\u003e\n\u003ctd\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eIsotype\u003c\/th\u003e\n\u003ctd\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd\u003eHuman, Mouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eConcentration\u003c\/th\u003e\n\u003ctd\u003e1 mg\/ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eObserved Band (kDa)\u003c\/th\u003e\n\u003ctd\u003e34kD\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003e-20°C\/1 year\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\n\u003ch2\u003eReactivity Notes\u003c\/h2\u003e\n\u003cp\u003eConfirmed reactivity in \u003cstrong\u003eHuman, Mouse\u003c\/strong\u003e samples; validated for \u003cstrong\u003eWestern Blot, ELISA\u003c\/strong\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eFor Research Use Only (RUO). Not intended for diagnostic procedures.\u003c\/li\u003e\n\u003cli\u003eShipping: cold-chain shipment (typically with ice packs).\u003c\/li\u003e\n\u003cli\u003eUpon receipt: store at recommended temperature as soon as possible.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSales terms and conditions\u003c\/strong\u003e: Please review prior to ordering.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cp\u003eExplore additional antibodies and related detection reagents for \u003cstrong\u003eSPY2\u003c\/strong\u003e in the BioHippo catalog.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"ELK Biotechnology","offers":[{"title":"50 uL","offer_id":53327759671661,"sku":"ES11940-50UL","price":192.4,"currency_code":"USD","in_stock":true},{"title":"100 uL","offer_id":53327764488557,"sku":"ES11940-100UL","price":322.4,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ES11940-c-1.jpg?v=1778727141","url":"https:\/\/www.ebiohippo.com\/products\/spy2-rabbit-pab-bha15210941","provider":"BioHippo","version":"1.0","type":"link"}