{"product_id":"sqor-antibody-sulfide-quinone-oxidoreductase-sqrdl-bha17136006","title":"SQOR Antibody \/ Sulfide quinone oxidoreductase \/ SQRDL","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSQOR Antibody \/ Sulfide quinone oxidoreductase \/ SQRDL is a anti-SQOR Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human. Reported localization: Cytoplasm (Mitochondria).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SQOR\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSQOR antibody detects Sulfide quinone oxidoreductase, a mitochondrial enzyme that catalyzes the first step in hydrogen sulfide oxidation. The UniProt recommended name is Sulfide:quinone oxidoreductase (SQOR). Also known as Sulfide quinone reductase-like protein (SQRDL), this flavoprotein converts toxic hydrogen sulfide to persulfide intermediates, linking sulfur metabolism to cellular respiration.\u003cbr\u003e\u003cbr\u003eFunctionally, SQOR antibody identifies a 450-amino-acid mitochondrial inner membrane enzyme containing a covalently bound FAD cofactor. SQOR transfers electrons from hydrogen sulfide to ubiquinone, producing reduced ubiquinol for the respiratory chain while forming a persulfide on its catalytic cysteine residue. This reaction detoxifies sulfide and integrates it into mitochondrial energy metabolism.\u003cbr\u003e\u003cbr\u003eThe SQOR gene is located on chromosome 15q26.1 and is widely expressed, with highest levels in liver, kidney, and heart. It is localized to the mitochondrial inner membrane facing the intermembrane space, forming part of the mitochondrial sulfide oxidation pathway along with ETHE1, TST, and SUOX. SQOR activity ensures sulfide homeostasis and prevents respiratory inhibition by excess H2S.\u003cbr\u003e\u003cbr\u003ePathologically, SQOR deficiency disrupts sulfide metabolism, leading to mitochondrial dysfunction and oxidative stress. Altered expression has been observed in cardiovascular disease, ischemia-reperfusion injury, and metabolic disorders. By maintaining sulfide balance, SQOR contributes to redox regulation and cellular protection. Research using SQOR antibody aids in studying sulfur metabolism, mitochondrial bioenergetics, and redox biology.\u003cbr\u003e\u003cbr\u003eSQOR antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence to detect mitochondrial sulfur oxidation enzymes. \u003cbr\u003e\u003cbr\u003eStructurally, Sulfide:quinone oxidoreductase features an FAD-binding domain and transmembrane regions anchoring it to the inner mitochondrial membrane. Its catalytic mechanism involves cysteine persulfide intermediates and electron transfer to coenzyme Q. This antibody enables investigation of SQOR's enzymatic role in sulfur and redox metabolism.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SQOR - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SQOR - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SQOR - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SQOR - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SQOR+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047313301869,"sku":"FY13104","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5b3760d0-f10d-41f8-83f7-0b1115bdb64e.jpg?v=1782237106","url":"https:\/\/www.ebiohippo.com\/products\/sqor-antibody-sulfide-quinone-oxidoreductase-sqrdl-bha17136006","provider":"BioHippo","version":"1.0","type":"link"}