{"product_id":"srarp-antibody-steroid-receptor-associated-and-regulated-protein-bha17135687","title":"SRARP Antibody \/ Steroid receptor-associated and regulated protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSRARP Antibody \/ Steroid receptor-associated and regulated protein is a anti-SRARP Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), ELISA with listed reactivity in Human. Reported localization: Cytoplasm, Nucleus.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SRARP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSRARP antibody detects Steroid receptor-associated and regulated protein, a nuclear transcriptional regulator that modulates retinoic acid and estrogen receptor signaling. Encoded by the SRARP gene on chromosome 1p36.12, this protein functions as a transcriptional cofactor influencing gene expression during development and cellular differentiation. SRARP contains LXXLL motifs characteristic of nuclear receptor cofactors and acts as both a transcriptional regulator and target of steroid hormone pathways.\u003cbr\u003e\u003cbr\u003eSRARP is expressed in hormone-responsive tissues including the brain, ovary, testis, and endometrium. It interacts with nuclear receptors such as estrogen receptor alpha (ERalpha) and retinoic acid receptor (RAR), modulating transcriptional output in a ligand-dependent manner. Through these interactions, SRARP influences gene networks governing cell cycle progression, neurogenesis, and reproductive tissue differentiation. Its expression is hormonally regulated, increasing in response to estrogen and decreasing under conditions of hormone withdrawal.\u003cbr\u003e\u003cbr\u003eThe SRARP antibody is widely used in endocrinology, neurobiology, and developmental research to study transcriptional regulation and steroid receptor signaling. Western blot analysis typically identifies a 27 kilodalton band corresponding to SRARP, while immunofluorescence shows nuclear localization in hormone-responsive cells. This antibody enables characterization of SRARP's role in receptor signaling and target gene transcription.\u003cbr\u003e\u003cbr\u003eDysregulation of SRARP expression has been linked to altered reproductive function and hormone-dependent cancers, including breast and ovarian carcinoma. SRARP may function as a modulator balancing proliferative and differentiation signals in response to hormonal cues. The SRARP antibody provides a key reagent for exploring transcriptional networks influenced by steroid receptors.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SRARP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SRARP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SRARP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SRARP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SRARP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047300030829,"sku":"FY12784","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_abccea9b-2d7e-4d53-bb04-95744e458933.jpg?v=1782237043","url":"https:\/\/www.ebiohippo.com\/products\/srarp-antibody-steroid-receptor-associated-and-regulated-protein-bha17135687","provider":"BioHippo","version":"1.0","type":"link"}