{"product_id":"srbd1-antibody-s1-rna-binding-domain-containing-protein-1-bha17136149","title":"SRBD1 Antibody \/ S1 RNA-binding domain-containing protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSRBD1 Antibody \/ S1 RNA-binding domain-containing protein 1 is a anti-SRBD1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, Mitochondria.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SRBD1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSRBD1 antibody detects S1 RNA-binding domain-containing protein 1, a nuclear and cytoplasmic protein involved in RNA metabolism, ribosome biogenesis, and cell cycle regulation. The UniProt recommended name is S1 RNA-binding domain-containing protein 1 (SRBD1). This multifunctional protein contains an S1-type RNA-binding domain that associates with ribosomal subunits and regulatory RNAs, linking gene expression control to cellular proliferation and differentiation.\u003cbr\u003e\u003cbr\u003eFunctionally, SRBD1 antibody identifies a 1,364-amino-acid protein that interacts with ribosomal proteins and RNA helicases to facilitate ribosome maturation and rRNA processing. SRBD1 binds pre-rRNA intermediates and assists in their folding, modification, and assembly into mature ribosomal subunits. It also participates in RNA quality control and nonsense-mediated decay pathways, ensuring translational fidelity and RNA stability. In addition to its RNA-binding activity, SRBD1 influences transcriptional regulation and DNA replication by interacting with chromatin-associated complexes.\u003cbr\u003e\u003cbr\u003eThe SRBD1 gene is located on chromosome 2q31.1 and is expressed in proliferative tissues such as bone marrow, liver, and testis. Expression increases during active cell growth and decreases under stress or differentiation signals. SRBD1 activity coordinates ribosome assembly with cellular growth requirements, making it essential for protein synthesis homeostasis.\u003cbr\u003e\u003cbr\u003ePathologically, SRBD1 mutations and altered expression have been linked to cancer, developmental disorders, and glaucoma susceptibility. Overexpression may promote tumorigenesis by enhancing ribosome biogenesis and proliferation, while reduced SRBD1 disrupts translation and leads to genomic instability. Research using SRBD1 antibody supports studies in RNA biology, ribosome assembly, and oncogenic transformation.\u003cbr\u003e\u003cbr\u003eSRBD1 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect RNA-binding proteins. \u003cbr\u003e\u003cbr\u003eStructurally, S1 RNA-binding domain-containing protein 1 possesses an S1-type RNA-binding motif and multiple coiled-coil and low-complexity regions that mediate protein-protein and RNA interactions. This modular structure allows SRBD1 to serve as a scaffold linking RNA metabolism to nuclear and cytoplasmic processes. This antibody enables the investigation of SRBD1's role in ribosome formation and its regulation of gene expression and cellular growth.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SRBD1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SRBD1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SRBD1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SRBD1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SRBD1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047319658861,"sku":"FY13247","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b4ef36ad-6148-4b1c-a855-409ed6bd88a6.jpg?v=1782237088","url":"https:\/\/www.ebiohippo.com\/products\/srbd1-antibody-s1-rna-binding-domain-containing-protein-1-bha17136149","provider":"BioHippo","version":"1.0","type":"link"}