{"product_id":"srpx-antibody-sushi-repeat-containing-protein-x-linked-bha17136212","title":"SRPX Antibody \/ Sushi repeat-containing protein X-linked","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSRPX Antibody \/ Sushi repeat-containing protein X-linked is a anti-SRPX Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SRPX\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSRPX antibody detects Sushi repeat-containing protein X-linked, a secreted and membrane-associated glycoprotein encoded by the SRPX gene located on chromosome Xq22.1. SRPX is a member of the sushi repeat (also called complement control protein or CCP) family, characterized by tandemly repeated domains that mediate protein-protein interactions involved in immune signaling, cell adhesion, and extracellular matrix organization. The SRPX protein localizes to the extracellular space and plasma membrane, where it participates in cellular communication, angiogenesis, and synaptic remodeling.\u003cbr\u003e\u003cbr\u003eSRPX antibody identifies a multifunctional protein expressed in various tissues, including the brain, lung, and vascular endothelium. Within the extracellular environment, SRPX acts as an adhesion molecule that facilitates interactions between cells and matrix components. It is upregulated during wound healing and tissue remodeling, suggesting a role in extracellular matrix turnover and endothelial migration. SRPX contains three sushi domains, an N-terminal signal peptide, and glycosylation sites that support secretion and stability in the extracellular milieu.\u003cbr\u003e\u003cbr\u003eIn the nervous system, SRPX contributes to synapse formation and refinement. A related paralog, SRPX2, has been implicated in synaptic development and language-associated brain disorders, suggesting possible functional overlap within this protein family. SRPX also interacts with urokinase-type plasminogen activator receptor (uPAR) and complement components, supporting its role in both immune regulation and neurodevelopment. The presence of sushi domains links SRPX to complement control proteins that regulate immune activation and inflammation. Functional studies suggest that SRPX can influence cell migration, angiogenic responses, and matrix protease activity, making it relevant in vascular biology and tumor progression.\u003cbr\u003e\u003cbr\u003eClinically, altered SRPX expression has been observed in cancer, where it may contribute to tumor angiogenesis and metastasis. Overexpression has been reported in certain carcinomas, whereas decreased expression may impair extracellular signaling and cell adhesion. SRPX mutations have been studied in relation to X-linked intellectual disability and speech delay, although functional evidence remains limited. The SRPX gene resides in a genomic region frequently associated with inherited neurological disorders and may have regulatory overlap with neighboring genes involved in synaptic signaling.\u003cbr\u003e\u003cbr\u003eFrom a structural standpoint, SRPX shares sequence homology with complement control proteins and contains conserved cysteine residues essential for disulfide bond formation. Its extracellular localization allows it to function as a scaffold in tissue remodeling and immune recognition. The protein family classification places SRPX among sushi domain-containing adhesion molecules, emphasizing its dual role in immune defense and neuronal plasticity.\u003cbr\u003e\u003cbr\u003eImmunohistochemical analysis using SRPX antibody demonstrates extracellular and membrane-associated localization in endothelial cells, neurons, and epithelial tissues. The SRPX antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SRPX - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SRPX - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SRPX - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SRPX - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SRPX+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047322345837,"sku":"FY13310","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f8d55112-0612-4b8e-b1d6-5841596720ac.jpg?v=1782237107","url":"https:\/\/www.ebiohippo.com\/products\/srpx-antibody-sushi-repeat-containing-protein-x-linked-bha17136212","provider":"BioHippo","version":"1.0","type":"link"}