{"product_id":"srr-antibody-serine-racemase-bha17136087","title":"SRR Antibody \/ Serine racemase","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSRR Antibody \/ Serine racemase is a anti-SRR Rabbit antibody Recombinant Rabbit Monoclonal clone 30S73 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SRR\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30S73, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSRR antibody detects Serine racemase, encoded by the SRR gene. Serine racemase is a pyridoxal phosphate dependent enzyme that catalyzes the conversion of L-serine to D-serine. D-serine functions as a co-agonist at NMDA receptors in the brain, where it modulates synaptic plasticity, learning, and memory. SRR antibody provides researchers with a specific reagent to study neurotransmission, amino acid metabolism, and neuropsychiatric disease.\u003cbr\u003e\u003cbr\u003eSerine racemase is expressed primarily in astrocytes and neurons, where it controls production of D-serine in the central nervous system. Research using SRR antibody has shown that D-serine binds to the glycine site of NMDA receptors, regulating receptor activation. This makes SRR activity essential for synaptic plasticity, long-term potentiation, and cognitive function. Loss of D-serine production due to impaired SRR activity results in deficits in NMDA receptor signaling.\u003cbr\u003e\u003cbr\u003eDysregulation of Serine racemase is linked to neurological and psychiatric disorders. Studies with SRR antibody have revealed that reduced activity contributes to schizophrenia by decreasing D-serine availability and NMDA receptor function. Conversely, excessive D-serine production may promote excitotoxicity and neurodegeneration in conditions such as amyotrophic lateral sclerosis and Alzheimer's disease. These findings position SRR as both a biomarker and a potential therapeutic target.\u003cbr\u003e\u003cbr\u003eBeyond the brain, Serine racemase contributes to metabolism and signaling in peripheral tissues. Research using SRR antibody has suggested roles in kidney function and immune regulation. Because D-serine influences both neural and systemic physiology, SRR is an enzyme with broad biological significance.\u003cbr\u003e\u003cbr\u003eSRR antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects full-length and truncated forms, immunohistochemistry highlights expression in brain regions, and immunofluorescence demonstrates astrocytic and neuronal localization. These applications make SRR antibody versatile in neuroscience and physiology research.\u003cbr\u003e\u003cbr\u003eBy supplying validated SRR antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SRR - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SRR - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SRR - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SRR - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SRR+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047318249837,"sku":"FY13185","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_64c6e69e-b78e-4bb5-9534-be6da6df3a51.jpg?v=1772019405","url":"https:\/\/www.ebiohippo.com\/products\/srr-antibody-serine-racemase-bha17136087","provider":"BioHippo","version":"1.0","type":"link"}