{"product_id":"stable-receptor-related-protein-rap-lrp1-inhibitor-bhp21403826","title":"Stable Receptor Related Protein (RAP) LRP1 Inhibitor","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eTarget identity:\u003c\/strong\u003e\u003cstrong\u003eRAP\u003c\/strong\u003e is a cell-surface receptor \/ receptor domain. It is typically cell membrane (often with extracellular ligand-binding region).\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRAP\u003c\/strong\u003e is provided as a recombinant protein reagent for \u003cstrong\u003eresearch use only\u003c\/strong\u003e. Recombinant proteins are commonly used as defined molecular inputs in biochemical and cell-free systems, enabling controlled interrogation of binding, activity, and pathway-relevant interactions.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProtein identity context:\u003c\/strong\u003e RAP (approx. molecular weight 42.00 kDa).\u003c\/p\u003e\u003ch2\u003eBiological significance and function\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eRAP\u003c\/strong\u003e is positioned at the interface between extracellular cues and intracellular signaling, where ligand binding can reorganize receptor complexes and propagate downstream pathway activation. Recombinant receptor domains are often used to dissect binding determinants and interaction specificity in vitro. This target is frequently explored in \u003cstrong\u003eCell Signaling\u003c\/strong\u003e research contexts.\u003c\/p\u003e\u003ch2\u003eMolecular characteristics\u003c\/h2\u003e\u003cp\u003eKey molecular attributes can influence binding behavior, stability, and assay background—especially for multimeric, disulfide-rich, or PTM-dependent targets.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular weight:\u003c\/strong\u003e 42.00 kDa\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;90%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003ePost-translational considerations:\u003c\/strong\u003e Expression host can influence folding and PTMs (e.g., glycosylation, disulfide bonds), which may impact stability or binding depending on protein class. For receptor ectodomains, folding and glycosylation can influence ligand binding and epitope presentation.\u003c\/p\u003e\u003ch2\u003eStructural and biochemical features\u003c\/h2\u003e\u003cp\u003eReceptor ectodomains can adopt multiple conformations and may require disulfide bonding and glycosylation for native-like binding surfaces, depending on target class.\u003c\/p\u003e\u003ch2\u003eExpression and purification strategy\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003ePurification:\u003c\/strong\u003e Affinity-chromatography. Purification approach and formulation influence sample homogeneity and background signal in downstream biochemical measurements.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eEndotoxin consideration:\u003c\/strong\u003e Reported endotoxin level is Please contact with the lab for this information.; this parameter can matter when recombinant proteins are used in cell-based systems sensitive to innate immune activation.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Reconstitute in sterile water for a stock solution..\u003c\/p\u003e\u003ch2\u003eResearch interpretation\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eResearch interpretation:\u003c\/strong\u003e Receptor activity frequently depends on ligand binding, receptor density, and complex assembly. In vitro binding measurements can help separate affinity\/specificity effects from downstream cellular amplification.\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"100 ug","offer_id":53000970404205,"sku":"HB705022-100UG","price":478.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53000970436973,"sku":"HB705022-1MG","price":2878.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HB705022-SDSPAGE-1.jpg?v=1770275199","url":"https:\/\/www.ebiohippo.com\/products\/stable-receptor-related-protein-rap-lrp1-inhibitor-bhp21403826","provider":"BioHippo","version":"1.0","type":"link"}