{"product_id":"stam2-antibody-signal-transducing-adaptor-molecule-2-bha17135992","title":"STAM2 Antibody \/ Signal transducing adaptor molecule 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTAM2 Antibody \/ Signal transducing adaptor molecule 2 is a anti-STAM2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Western blot (WB), Flow cytometry (FACS) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STAM2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e ELISA, IF, ICC, WB, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTAM2 antibody detects Signal transducing adaptor molecule 2, a component of the endosomal sorting complex required for transport (ESCRT-0) that regulates receptor-mediated endocytosis and signal downregulation. The UniProt recommended name is Signal transducing adaptor molecule 2 (STAM2). This adaptor protein cooperates with HGS to recognize ubiquitinated cargo and recruit downstream ESCRT machinery for lysosomal degradation.\u003cbr\u003e\u003cbr\u003eFunctionally, STAM2 antibody identifies a 512-amino-acid cytosolic protein containing VHS, SH3, and ubiquitin-interacting motifs. STAM2 binds to HGS, clathrin, and ubiquitinated receptors, guiding cargo sorting into multivesicular bodies. By directing receptor trafficking, STAM2 attenuates signaling from growth factor receptors, cytokine receptors, and immune complexes.\u003cbr\u003e\u003cbr\u003eThe STAM2 gene is located on chromosome 2p13.1 and is expressed ubiquitously, with high abundance in immune and epithelial cells. STAM2 functions downstream of activated receptors such as EGFR, ensuring signal termination through endosomal sorting. Its interaction with tyrosine kinases and deubiquitinating enzymes provides regulatory balance between receptor activation and degradation.\u003cbr\u003e\u003cbr\u003ePathologically, disrupted STAM2 expression or mutation can impair receptor turnover, leading to prolonged signaling and oncogenic transformation. Overactivation of endocytic pathways involving STAM2 has been implicated in cancer and immune dysregulation. Research using STAM2 antibody helps elucidate receptor trafficking, ubiquitin signaling, and endosomal dynamics.\u003cbr\u003e\u003cbr\u003eSTAM2 antibody is suitable for western blotting, immunoprecipitation, and immunofluorescence to detect ESCRT-0 complex components and study receptor endocytosis. \u003cbr\u003e\u003cbr\u003eStructurally, STAM2 contains an N-terminal VHS domain for cargo recognition, a central SH3 domain mediating protein interactions, and C-terminal ubiquitin-binding motifs. This configuration allows STAM2 to integrate receptor internalization with signaling termination. This antibody supports investigations into vesicular trafficking and cell signaling regulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STAM2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STAM2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STAM2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STAM2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STAM2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047311434093,"sku":"FY13090","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9c9814ce-6bef-4752-a7e8-a90d63527a78.jpg?v=1782237084","url":"https:\/\/www.ebiohippo.com\/products\/stam2-antibody-signal-transducing-adaptor-molecule-2-bha17135992","provider":"BioHippo","version":"1.0","type":"link"}