{"product_id":"stard10-antibody-star-related-lipid-transfer-protein-10-pctp-l-bha17135892","title":"STARD10 Antibody \/ StAR-related lipid transfer protein 10 \/ PCTP-L","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTARD10 Antibody \/ StAR-related lipid transfer protein 10 \/ PCTP-L is a anti-STARD10 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Flow cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC), Western blot (WB) with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STARD10\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e ELISA, FACS, IF, ICC, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTARD10 antibody detects StAR-related lipid transfer protein 10, a cytosolic lipid-binding protein that regulates intracellular lipid trafficking and membrane composition. The UniProt recommended name is StAR-related lipid transfer protein 10 (STARD10). This protein belongs to the START domain-containing family, which mediates non-vesicular lipid transfer between organelles and participates in lipid metabolism and signaling.\u003cbr\u003e\u003cbr\u003eFunctionally, STARD10 antibody identifies a 329-amino-acid protein that binds phosphatidylcholine, phosphatidylethanolamine, and other phospholipids through its conserved steroidogenic acute regulatory-related lipid transfer (START) domain. STARD10 facilitates the exchange and transport of phospholipids between membranes, ensuring proper lipid composition of the Golgi apparatus, plasma membrane, and endoplasmic reticulum. It plays important roles in membrane biogenesis, vesicle formation, and signal transduction.\u003cbr\u003e\u003cbr\u003eThe STARD10 gene is located on chromosome 11q13.1 and is expressed in multiple tissues, including pancreas, liver, and brain. In pancreatic beta cells, STARD10 modulates insulin secretion by regulating lipid signaling and granule membrane dynamics. Genetic studies have linked STARD10 variants to type 2 diabetes susceptibility, indicating its role in glucose metabolism and endocrine function. Its expression is also responsive to cellular lipid levels and nutrient signaling pathways, suggesting involvement in metabolic adaptation.\u003cbr\u003e\u003cbr\u003eIn lipid metabolism, STARD10 contributes to maintaining phospholipid asymmetry and membrane curvature. It interacts with small GTPases and cytoskeletal components to regulate vesicle trafficking. Dysregulation of STARD10 affects lipid homeostasis and has been associated with metabolic disorders and cancer. Elevated STARD10 expression has been observed in breast and pancreatic cancers, where it may influence membrane signaling and cell proliferation.\u003cbr\u003e\u003cbr\u003eSTARD10 antibody is widely used in cell biology, metabolism, and endocrinology research. It is suitable for immunoblotting, immunofluorescence, and lipid transport assays to study protein localization and lipid-binding activity. Detection of STARD10 aids in exploring lipid trafficking pathways and their impact on cellular signaling. In disease models, STARD10 antibody supports studies on insulin secretion, metabolic regulation, and tumor lipid metabolism.\u003cbr\u003e\u003cbr\u003eStructurally, STARD10 consists of a single START domain forming a hydrophobic binding pocket that accommodates phospholipid molecules. Post-translational modifications such as phosphorylation and acetylation regulate its lipid affinity and subcellular localization.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STARD10 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STARD10 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STARD10 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STARD10 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STARD10+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047308452205,"sku":"FY12990","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_7ee69554-f6a9-4fd0-bf51-a3641f5472ea.jpg?v=1782237073","url":"https:\/\/www.ebiohippo.com\/products\/stard10-antibody-star-related-lipid-transfer-protein-10-pctp-l-bha17135892","provider":"BioHippo","version":"1.0","type":"link"}