{"product_id":"stat2-antibody-signal-transducer-and-activator-of-transcription-2-bha17135747","title":"STAT2 Antibody \/ Signal transducer and activator of transcription 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTAT2 Antibody \/ Signal transducer and activator of transcription 2 is a anti-STAT2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STAT2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTAT2 antibody detects Signal transducer and activator of transcription 2, a transcription factor central to interferon (IFN) signaling and antiviral defense. Encoded by the STAT2 gene on chromosome 12q13.2, this protein is a member of the STAT family of latent cytoplasmic transcription factors that transmit signals from cytokine receptors to the nucleus. STAT2 is activated by phosphorylation in response to type I interferons (IFN-alpha and IFN-beta), forming part of the ISGF3 (interferon-stimulated gene factor 3) transcriptional complex with STAT1 and IRF9 to regulate antiviral gene expression.\u003cbr\u003e\u003cbr\u003eUpon cytokine stimulation, STAT2 undergoes phosphorylation on tyrosine 690 by Janus kinases (JAK1 and TYK2), dimerizes with STAT1, and associates with IRF9. This trimeric complex translocates to the nucleus, where it binds interferon-stimulated response elements (ISREs) in the promoters of interferon-stimulated genes (ISGs), initiating transcription of antiviral effectors such as OAS1, MX1, and ISG15. These gene products suppress viral replication and enhance immune defense mechanisms.\u003cbr\u003e\u003cbr\u003eThe STAT2 antibody is widely used in immunology, virology, and cell signaling research to examine interferon pathways, innate immune activation, and transcriptional regulation. Western blot analysis detects a 113 kilodalton band corresponding to STAT2, while immunofluorescence reveals both cytoplasmic and nuclear staining following interferon treatment. This antibody enables detailed analysis of IFN-mediated signal transduction and transcriptional regulation in various immune and epithelial cell types.\u003cbr\u003e\u003cbr\u003eSTAT2 plays a critical role not only in antiviral immunity but also in inflammation, cancer immunosurveillance, and immune tolerance. Deficiency or mutation of STAT2 causes severe susceptibility to viral infections due to impaired interferon signaling, while persistent activation of the JAK-STAT pathway is associated with tumor progression and chronic inflammation. The STAT2 antibody supports exploration of these processes and evaluation of therapeutic modulation of interferon pathways.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STAT2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STAT2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STAT2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STAT2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STAT2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047304421741,"sku":"FY12845","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_755c5c1d-92ef-4a36-9896-7aedf846a4cf.jpg?v=1782237059","url":"https:\/\/www.ebiohippo.com\/products\/stat2-antibody-signal-transducer-and-activator-of-transcription-2-bha17135747","provider":"BioHippo","version":"1.0","type":"link"}