{"product_id":"sting1-antibody-stimulator-of-interferon-genes-tmem173-bha17135924","title":"STING1 Antibody \/ Stimulator of interferon genes \/ TMEM173","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTING1 Antibody \/ Stimulator of interferon genes \/ TMEM173 is a anti-STING1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, Nucleus.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STING1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTING1 antibody detects Stimulator of interferon genes (TMEM173), a central adaptor protein in the cytosolic DNA-sensing pathway that activates type I interferon responses. The UniProt recommended name is Stimulator of interferon genes (TMEM173). This transmembrane signaling protein is critical for innate immunity, serving as a bridge between cytosolic DNA detection and antiviral gene transcription.\u003cbr\u003e\u003cbr\u003eFunctionally, STING1 antibody identifies a 379-amino-acid endoplasmic reticulum (ER) adaptor protein that senses cyclic dinucleotides (CDNs) generated by the DNA sensor cGAS. Upon binding to cyclic GMP-AMP (cGAMP), STING undergoes conformational changes and translocates from the ER to the Golgi apparatus, where it recruits and activates the kinase TBK1. Activated TBK1 phosphorylates IRF3, triggering transcription of interferon-stimulated genes and cytokines such as IFN-beta, establishing an antiviral state.\u003cbr\u003e\u003cbr\u003eThe TMEM173 gene is located on chromosome 5q31.2 and encodes a conserved multi-pass transmembrane protein expressed in immune, epithelial, and endothelial cells. STING signaling not only defends against viral infection but also detects self-DNA released during cellular stress, DNA damage, or mitochondrial leakage. While crucial for host defense, persistent STING activation can drive autoinflammation, tissue injury, and autoimmune disease.\u003cbr\u003e\u003cbr\u003eSTING functions as a master regulator of cytosolic DNA responses, mediating immune recognition of viral, bacterial, and tumor DNA. Gain-of-function mutations in TMEM173 cause STING-associated vasculopathy with onset in infancy (SAVI), a severe autoinflammatory disorder characterized by excessive interferon signaling. Conversely, impaired STING activation increases susceptibility to infection and impedes tumor immune surveillance. In oncology, STING serves as a therapeutic target for cancer immunotherapy, where agonists are used to boost antitumor immunity through interferon induction and dendritic cell activation.\u003cbr\u003e\u003cbr\u003eSTING antibody is widely used in immunology, oncology, and inflammation research. It is suitable for western blotting, immunofluorescence, and immunoprecipitation to detect endogenous STING protein and study its activation dynamics. This antibody supports investigations into innate immune signaling, interferon pathway regulation, and host-pathogen interactions. In cancer studies, STING detection helps evaluate immune activation following treatment with STING agonists or DNA-damaging agents.\u003cbr\u003e\u003cbr\u003eStructurally, STING forms a homodimer with a cytosolic ligand-binding domain that interacts with cGAMP and CDNs. The protein contains four transmembrane helices anchoring it to the ER membrane and a C-terminal tail essential for TBK1 and IRF3 recruitment.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STING1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STING1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STING1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STING1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STING1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047309664621,"sku":"FY13022","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_e8d82109-3d50-4c99-8ec8-56214021ca18.jpg?v=1782237066","url":"https:\/\/www.ebiohippo.com\/products\/sting1-antibody-stimulator-of-interferon-genes-tmem173-bha17135924","provider":"BioHippo","version":"1.0","type":"link"}