{"product_id":"stk16-antibody-serine-threonine-protein-kinase-16-bha17135984","title":"STK16 Antibody \/ Serine\/threonine-protein kinase 16","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTK16 Antibody \/ Serine\/threonine-protein kinase 16 is a anti-STK16 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS) with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, Nucleus, Cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STK16\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e ELISA, WB, IHC, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTK16 antibody detects Serine\/threonine-protein kinase 16, a membrane-associated kinase that regulates secretion, Golgi organization, and intracellular trafficking. The UniProt recommended name is Serine\/threonine-protein kinase 16 (STK16). This constitutively active kinase associates with the Golgi apparatus and modulates vesicular transport between the Golgi and plasma membrane.\u003cbr\u003e\u003cbr\u003eFunctionally, STK16 antibody identifies a 305-amino-acid protein with a typical serine\/threonine kinase domain and a C-terminal myristoylation site that anchors it to membranes. STK16 phosphorylates various substrates involved in exocytosis, including components of the SNARE complex. It is essential for maintaining Golgi structure, regulating secretion, and coordinating protein sorting within the secretory pathway.\u003cbr\u003e\u003cbr\u003eThe STK16 gene is located on chromosome 2q31.1 and is ubiquitously expressed, with enrichment in liver, pancreas, and secretory epithelial tissues. STK16�s kinase activity is regulated by autophosphorylation and membrane association. It also participates in cell cycle progression and polarized transport, suggesting broader roles in organelle biogenesis and signal transduction.\u003cbr\u003e\u003cbr\u003ePathologically, aberrant STK16 function has been implicated in tumorigenesis, metabolic disease, and Golgi stress. Overexpression may enhance secretion and proliferation, while inhibition disrupts vesicular trafficking and protein glycosylation. Research using STK16 antibody contributes to understanding kinase-mediated control of membrane traffic and its implications in disease and cellular physiology.\u003cbr\u003e\u003cbr\u003eSTK16 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to visualize Golgi-associated kinases and phosphorylation-dependent trafficking. \u003cbr\u003e\u003cbr\u003eStructurally, STK16 belongs to the NAK (Numb-associated kinase) family and features an N-lobe typical of protein kinases, with regulatory elements that stabilize its constitutive activity. This antibody supports detailed characterization of STK16's role in kinase signaling and Golgi organization.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STK16 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STK16 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STK16 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STK16 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STK16+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047311565165,"sku":"FY13082","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_701a82f0-b21d-4087-97b4-9f270c994032.jpg?v=1782237087","url":"https:\/\/www.ebiohippo.com\/products\/stk16-antibody-serine-threonine-protein-kinase-16-bha17135984","provider":"BioHippo","version":"1.0","type":"link"}