{"product_id":"stk26-antibody-mst4-mask-bha17135325","title":"STK26 Antibody \/ MST4 \/ MASK","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTK26 Antibody \/ MST4 \/ MASK is a anti-STK26 Rabbit antibody Recombinant Rabbit Monoclonal clone 29S79 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, Golgi.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STK26\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29S79, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTK26 antibody recognizes serine threonine kinase 26, a signaling kinase that participates in cell proliferation, apoptosis, and polarity regulation. STK26, sometimes referred to as MST4 or MASK associated protein, is a member of the germinal center kinase family. It is encoded by the STK26 gene and functions downstream of multiple signaling pathways including the Hippo pathway. Through phosphorylation of substrates involved in cytoskeletal dynamics and transcriptional regulation, STK26 contributes to cellular architecture and growth control.\u003cbr\u003e\u003cbr\u003eSTK26 antibody is commonly applied in studies of cancer, epithelial polarity, and kinase signaling. In epithelial cells, STK26 regulates apical basal polarity and tissue organization. In cancer, STK26 expression has been associated with tumor progression, migration, and invasion. By detecting STK26 expression, researchers can examine how dysregulation of this kinase influences malignancy and whether it serves as a useful biomarker.\u003cbr\u003e\u003cbr\u003eThe antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence. In western blot assays, STK26 antibody detects protein bands corresponding to the expected size, confirming expression across different samples. Immunohistochemistry highlights tissue localization of the kinase, while immunofluorescence provides single cell resolution of its cytoplasmic and membrane associated distribution. These applications make STK26 antibody a versatile tool for exploring kinase activity in diverse biological contexts.\u003cbr\u003e\u003cbr\u003eResearch has shown that STK26 interacts with adaptor proteins such as MASK and kinases like MST4, forming scaffolding complexes that integrate signaling networks. These complexes influence cell polarity, cytoskeletal organization, and transcription factor regulation. STK26 is also implicated in Hippo signaling, a pathway that governs tissue size and cellular proliferation by balancing growth and apoptosis. By using STK26 antibody, scientists can evaluate how this kinase contributes to developmental biology and disease progression.\u003cbr\u003e\u003cbr\u003eIn oncology, altered STK26 expression has been reported in certain cancers, where its activity may support invasion and metastasis. Experimental models suggest that modulation of STK26 influences tumor cell migration, making it a potential therapeutic target. Beyond cancer, STK26 plays roles in tissue morphogenesis, neuronal polarity, and immune regulation. Antibodies against STK26 therefore support a broad range of research into cellular organization and signaling.\u003cbr\u003e\u003cbr\u003eSTK26 antibody provided by\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STK26 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STK26 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STK26 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STK26 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STK26+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047288955245,"sku":"FY12422","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c5e65a87-7648-4139-b4bb-9f69d7787b62.jpg?v=1782237005","url":"https:\/\/www.ebiohippo.com\/products\/stk26-antibody-mst4-mask-bha17135325","provider":"BioHippo","version":"1.0","type":"link"}