{"product_id":"stk31-antibody-serine-threonine-protein-kinase-31-bha17135901","title":"STK31 Antibody \/ Serine\/threonine-protein kinase 31","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTK31 Antibody \/ Serine\/threonine-protein kinase 31 is a anti-STK31 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STK31\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e ELISA, WB, IHC, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTK31 antibody detects Serine\/threonine-protein kinase 31, a testis-enriched kinase implicated in cell cycle regulation, chromatin organization, and germ cell development. The UniProt recommended name is Serine\/threonine-protein kinase 31 (STK31). This enzyme belongs to the TDRD (Tudor domain-containing) kinase family, which coordinates post-translational modifications and chromatin-associated signaling during meiosis and mitosis.\u003cbr\u003e\u003cbr\u003eFunctionally, STK31 antibody identifies an 888-amino-acid cytoplasmic and nuclear protein containing a serine\/threonine kinase domain and a Tudor domain that recognizes methylated arginine and lysine residues. STK31 acts as a scaffold linking chromatin dynamics to signaling pathways that govern cell division. In germ cells, it localizes to the chromatoid body, a specialized cytoplasmic structure involved in RNA processing and regulation during spermatogenesis. Its activity supports meiotic progression, chromatin condensation, and genomic stability.\u003cbr\u003e\u003cbr\u003eThe STK31 gene is located on chromosome 7p15.3 and is expressed predominantly in testis, with lower levels detected in certain somatic tissues and tumors. Its kinase activity regulates phosphorylation events critical for spindle assembly and chromosome alignment. Dysregulation of STK31 expression has been observed in various cancers, including colorectal, gastric, and breast carcinoma, where it may promote cell proliferation and migration through modulation of cytoskeletal organization and mitotic checkpoint control.\u003cbr\u003e\u003cbr\u003eIn cancer biology, STK31 is considered a cancer-testis antigen, reflecting its restricted normal expression but reactivation in tumors. Elevated expression enhances proliferation and resistance to apoptosis, suggesting potential as a therapeutic target or biomarker. STK31 overexpression also correlates with chromosomal instability and altered epigenetic landscapes in tumor cells.\u003cbr\u003e\u003cbr\u003eSTK31 antibody is widely used in cell cycle, germ cell biology, and oncology research. It is suitable for immunoblotting, immunofluorescence, and kinase activity assays to detect STK31 expression and subcellular localization. In reproductive biology, it supports studies of meiotic regulation, RNA granule organization, and germ cell maturation. In oncology, detection of STK31 contributes to understanding its role in tumorigenesis and potential as a prognostic marker.\u003cbr\u003e\u003cbr\u003eStructurally, STK31 comprises a conserved catalytic kinase domain, a Tudor domain for chromatin interactions, and regulatory sequences that control subcellular targeting. Its kinase activity may be regulated by phosphorylation and binding to scaffold proteins within the mitotic apparatus.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STK31 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STK31 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STK31 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STK31 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STK31+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047308616045,"sku":"FY12999","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_75e82923-da25-4001-82d6-ff14dc261eda.jpg?v=1782237073","url":"https:\/\/www.ebiohippo.com\/products\/stk31-antibody-serine-threonine-protein-kinase-31-bha17135901","provider":"BioHippo","version":"1.0","type":"link"}