{"product_id":"stk32c-antibody-serine-threonine-protein-kinase-32c-bha17135413","title":"STK32C Antibody \/ Serine\/threonine-protein kinase 32C","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTK32C Antibody \/ Serine\/threonine-protein kinase 32C is a anti-STK32C Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STK32C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTK32C antibody detects Serine\/threonine-protein kinase 32C, a member of the STK32 family of kinases that includes STK32A and STK32B. STK32C is a cytoplasmic serine\/threonine kinase involved in signal transduction pathways regulating cellular growth, metabolism, and stress responses. Although less characterized than its paralogs, STK32C has emerging importance in neuronal signaling and mitochondrial regulation. The STK32C antibody is used in research investigating kinase signaling networks, neurodevelopment, and protein phosphorylation control.\u003cbr\u003e\u003cbr\u003eSTK32C is encoded by the STK32C gene located on human chromosome 5q35.1. The protein is approximately 56 kilodaltons and contains a conserved serine\/threonine kinase catalytic domain with typical subdomains I-XI, including an ATP-binding site and an activation loop. Expression profiling shows broad distribution across tissues, with enriched levels in brain, heart, and skeletal muscle, suggesting roles in excitable tissue function and mitochondrial homeostasis.\u003cbr\u003e\u003cbr\u003eSTK32C phosphorylates substrates involved in metabolic regulation and cytoskeletal dynamics, though its full substrate repertoire remains under study. In neuronal systems, STK32C expression increases during differentiation, implying a developmental regulatory function. Comparative analysis with STK32A and STK32B reveals overlapping but distinct substrate preferences and signaling responses, highlighting potential functional diversification among this kinase subfamily.\u003cbr\u003e\u003cbr\u003eRecent phosphoproteomic analyses indicate that STK32C may participate in stress-activated signaling and mitochondrial fission control. Inhibition or silencing of STK32C disrupts mitochondrial morphology and reduces oxidative phosphorylation efficiency. This kinase may integrate metabolic status with energy homeostasis by phosphorylating mitochondrial or cytosolic target proteins. Additionally, preliminary data suggest a role in autophagic flux modulation and endoplasmic reticulum-mitochondria communication.\u003cbr\u003e\u003cbr\u003eIn cancer biology, STK32C has been implicated in cellular proliferation and invasion through phosphorylation of cytoskeletal effectors. Elevated expression correlates with poor prognosis in certain neuroblastoma and glioblastoma datasets, suggesting possible oncogenic behavior in nervous system tumors. In contrast, other studies report STK32C downregulation in degenerative neural conditions, implying context-dependent effects. The enzyme's unique sequence features, including an elongated C-terminal tail and regulatory motifs, suggest fine-tuned signaling modulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STK32C - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STK32C - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STK32C - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STK32C - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STK32C+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047291117933,"sku":"FY12510","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a279d9a5-e50a-4a6a-8c43-1567b1c69ec0.jpg?v=1782237011","url":"https:\/\/www.ebiohippo.com\/products\/stk32c-antibody-serine-threonine-protein-kinase-32c-bha17135413","provider":"BioHippo","version":"1.0","type":"link"}