{"product_id":"stoml3-antibody-stomatin-like-protein-3-bha17135661","title":"STOML3 Antibody \/ Stomatin-like protein 3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTOML3 Antibody \/ Stomatin-like protein 3 is a anti-STOML3 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STOML3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTOML3 antibody detects Stomatin-like protein 3, a membrane-associated modulator of mechanosensation and ion channel activity. Encoded by the STOML3 gene on chromosome 13q14.2, this protein belongs to the stomatin family, which includes membrane-bound scaffolding proteins involved in sensory transduction and membrane organization. STOML3 contains a conserved stomatin-like domain that mediates protein-lipid and protein-protein interactions, particularly with mechanosensitive ion channels such as PIEZO2 and ASICs. It localizes to vesicular and plasma membranes in sensory neurons, where it regulates mechanotransduction sensitivity.\u003cbr\u003e\u003cbr\u003eSTOML3 plays a crucial role in peripheral mechanosensation by enhancing the responsiveness of mechanosensitive ion channels to mechanical stimuli. It forms oligomeric complexes that influence channel gating and localization within mechanosensory end-organs. In dorsal root ganglion neurons, STOML3 interacts with PIEZO2 to amplify mechanosensitive currents required for touch and proprioception. Genetic deletion of STOML3 in mice leads to significant deficits in mechanical sensitivity without affecting nociception, demonstrating its specificity for tactile function.\u003cbr\u003e\u003cbr\u003eThe STOML3 antibody is widely used in neurobiology and sensory physiology research to detect Stomatin-like protein 3 and study its interactions with mechanosensory ion channels. Western blot analysis identifies a 32 kilodalton band corresponding to STOML3, while immunofluorescence shows punctate cytoplasmic staining in sensory neurons and mechanosensory tissues. The antibody allows visualization of STOML3 localization within neuronal projections and sensory end-organs, supporting investigations into the molecular basis of touch sensation.\u003cbr\u003e\u003cbr\u003eBeyond sensory neurons, STOML3 expression has been reported in lung and kidney tissues, suggesting broader roles in mechanotransduction and membrane curvature regulation. It may also participate in lipid raft organization and vesicular trafficking. The STOML3 antibody enables researchers to explore these processes and provides a key reagent for examining the molecular architecture of mechanosensitive signaling complexes.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STOML3 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STOML3 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STOML3 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STOML3 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STOML3+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047299408237,"sku":"FY12758","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_adc1c872-1fe9-41a0-a496-c68451cf5153.jpg?v=1782237056","url":"https:\/\/www.ebiohippo.com\/products\/stoml3-antibody-stomatin-like-protein-3-bha17135661","provider":"BioHippo","version":"1.0","type":"link"}