{"product_id":"stox2-antibody-storkhead-box-protein-2-bha17136238","title":"STOX2 Antibody \/ Storkhead box protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTOX2 Antibody \/ Storkhead box protein 2 is a anti-STOX2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STOX2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTOX2 antibody detects Storkhead box protein 2, a nuclear transcription factor encoded by the STOX2 gene located on chromosome 4q35.1. STOX2 belongs to the storkhead box protein family, characterized by winged-helix (forkhead-like) DNA-binding domains, and functions primarily in transcriptional regulation during embryonic development and placental differentiation. It is expressed in brain, placenta, and reproductive tissues, with developmental expression patterns suggesting a key role in early organogenesis and epithelial cell specification.\u003cbr\u003e\u003cbr\u003eSTOX2 regulates gene networks involved in cell differentiation, extracellular matrix formation, and immune modulation. As a nuclear transcription factor, it binds promoter and enhancer regions to modulate expression of developmental and hormonal response genes. STOX2 expression increases during embryogenesis and trophoblast development, indicating a function in maternal-fetal interface establishment. In adult tissues, it remains expressed in epithelial and endothelial cells, maintaining homeostasis and tissue-specific gene expression.\u003cbr\u003e\u003cbr\u003eStructurally, STOX2 contains a winged-helix DNA-binding domain typical of forkhead-like transcription factors, along with transactivation domains in its C-terminus that recruit transcriptional coactivators. It belongs to the storkhead box protein family, which includes STOX1�a transcription factor associated with preeclampsia�highlighting shared regulatory mechanisms in placental and vascular development. STOX2 may co-localize with transcriptional regulators such as SMADs in TGF-beta signaling, influencing epithelial differentiation and growth factor response.\u003cbr\u003e\u003cbr\u003eFunctionally, STOX2 contributes to placental morphogenesis and vascular remodeling. Its regulatory role in epithelial-mesenchymal transitions (EMT) and matrix deposition suggests involvement in tissue remodeling and wound repair. STOX2 may also modulate immune tolerance mechanisms at the maternal-fetal interface, ensuring proper placental development. In the nervous system, developmental expression studies show STOX2 activity during neuronal lineage specification, indicating broader roles beyond placentation.\u003cbr\u003e\u003cbr\u003eDysregulation of STOX2 expression has been associated with pregnancy-related disorders such as preeclampsia and intrauterine growth restriction. Aberrant promoter methylation or altered transcriptional regulation can disrupt placental gene networks. In cancer, reduced STOX2 levels have been linked to loss of epithelial integrity, while overexpression may contribute to tumor invasion through EMT activation. Pathway associations include TGF-beta signaling, Wnt signaling, and gene regulatory pathways governing developmental morphogenesis.\u003cbr\u003e\u003cbr\u003eSTOX2 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STOX2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STOX2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STOX2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STOX2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STOX2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047322837357,"sku":"FY13336","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_71808027-ad36-421c-85a8-012be07be520.jpg?v=1782237108","url":"https:\/\/www.ebiohippo.com\/products\/stox2-antibody-storkhead-box-protein-2-bha17136238","provider":"BioHippo","version":"1.0","type":"link"}