{"product_id":"strbp-antibody-spermatid-perinuclear-rna-binding-protein-bha17135313","title":"STRBP Antibody \/ Spermatid perinuclear RNA-binding protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTRBP Antibody \/ Spermatid perinuclear RNA-binding protein is a anti-STRBP Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STRBP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe STRBP antibody targets Spermatid perinuclear RNA-binding protein, a multifunctional RNA- and microtubule-associated protein encoded by the STRBP gene. Spermatid perinuclear RNA-binding protein is involved in RNA transport, post-transcriptional regulation, and microtubule organization. It contributes to spermatogenesis, neuronal differentiation, and stress granule assembly. The STRBP antibody provides researchers with a versatile reagent for investigating RNA-binding protein networks and cytoskeletal coordination during differentiation and stress responses.\u003cbr\u003e\u003cbr\u003eSpermatid perinuclear RNA-binding protein contains multiple double-stranded RNA-binding motifs (dsRBDs) and a leucine zipper domain that mediate RNA recognition and dimerization. It localizes to the cytoplasm and perinuclear region, where it associates with RNA granules and microtubules. The STRBP antibody supports detection of this localization, enabling studies of its role in mRNA transport and translational control. STRBP is particularly enriched in developing spermatids, where it participates in the storage and regulation of mRNAs required for sperm maturation.\u003cbr\u003e\u003cbr\u003eBeyond reproductive function, Spermatid perinuclear RNA-binding protein is expressed in multiple tissues, including brain and heart, where it modulates RNA metabolism and cytoskeletal integrity. It binds to microtubule-associated complexes to stabilize RNA localization during cellular polarization. The STRBP antibody enables visualization of these interactions, providing insight into how STRBP integrates RNA processing with cytoskeletal rearrangement in differentiating cells.\u003cbr\u003e\u003cbr\u003eSTRBP also plays a role in stress granule formation during cellular stress, interacting with proteins such as Staufen and DDX3X to regulate mRNA triage and translation repression. The STRBP antibody supports studies of these dynamic processes, helping to elucidate the molecular mechanisms underlying mRNA storage and recovery following stress exposure. Dysregulation of STRBP has been linked to infertility, neurodevelopmental disorders, and altered stress responses.\u003cbr\u003e\u003cbr\u003eThe STRBP antibody is validated for western blotting, immunofluorescence, and immunohistochemistry, producing strong cytoplasmic and perinuclear staining consistent with its RNA granule localization.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STRBP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STRBP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STRBP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STRBP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STRBP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047288824173,"sku":"FY12410","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d01bc616-1c6e-4aa8-a44f-a8a59d1a2fdc.jpg?v=1782237016","url":"https:\/\/www.ebiohippo.com\/products\/strbp-antibody-spermatid-perinuclear-rna-binding-protein-bha17135313","provider":"BioHippo","version":"1.0","type":"link"}