{"product_id":"streptolysin-o-protein-bhp10506052","title":"Streptolysin O protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eNative streptococcus hemolyticus streptolysin O (SLO) is purified from Streptococcus hemolyticus and supplied as a research reagent. It is commonly used as a reference material in biochemical and analytical workflows, and to support interpretation when naturally occurring proteoforms (for example, glycosylation or other post‑translational modifications) may matter.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eNative-source preparation:\u003c\/strong\u003e Purified from a biological source, which can be useful when studying naturally occurring proteoforms and complex formation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eMolecular form:\u003c\/strong\u003e Full length protein.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Attacin\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%(SDS-PAGE) (as reported).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eCommon names \/ aliases:\u003c\/strong\u003e SLO\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese elements help determine how the reagent behaves in binding, stability, or quantitative measurements, and how closely it reflects biology in the chosen model system.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eStreptolysin O (SLO) is a cholesterol-dependent cytolysin produced by certain Streptococcus species. After binding to cholesterol-containing membranes, it oligomerizes to form pores, making it a well-studied model for pore-forming toxins and membrane damage responses. SLO activity is sulfhydryl-activated and can be reversibly reduced by oxidation.\u003c\/p\u003e\u003cp\u003eSulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eHost–pathogen interaction research on pore-forming toxins and innate sensing of membrane damage.\u003c\/li\u003e \u003cli\u003eMembrane biophysics studies that use cytolysins to probe lipid dependence, oligomerization, and repair pathways.\u003c\/li\u003e \u003cli\u003eCellular stress signaling research linking membrane permeabilization to inflammasome activation and repair mechanisms (RUO).\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eMechanistic studies of pore formation and cholesterol-dependent membrane binding.\u003c\/li\u003e \u003cli\u003eTool reagent concepts in membrane biology where controlled permeabilization is investigated at a conceptual level.\u003c\/li\u003e \u003cli\u003eBenchmark antigen in immunology studies of streptococcal virulence factors.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eUse changes in abundance, binding, or activity readouts as context-dependent signals. In many systems, differences may reflect regulation, compartment shifts, complex formation, or sample-matrix effects rather than a single direct mechanism.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eSLO activity is sensitive to redox state and cholesterol availability; variation here can change apparent potency.\u003c\/li\u003e \u003cli\u003ePore-forming toxins can trigger multiple secondary cellular responses; interpret phenotypes with orthogonal markers of stress and viability.\u003c\/li\u003e \u003cli\u003eHandle and interpret SLO-related data within appropriate biosafety and RUO constraints.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt: https:\/\/www.uniprot.org\/uniprotkb?query=streptolysin O SLO cholesterol-dependent cytolysin - NCBI Gene: https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=streptolysin O SLO cholesterol-dependent cytolysin - PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=streptolysin O SLO cholesterol-dependent cytolysin%20review --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 g","offer_id":53052978233709,"sku":"CSB-NP078041Ba-1G","price":173335.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53052978266477,"sku":"CSB-NP078041Ba-100MG","price":26665.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53052978299245,"sku":"CSB-NP078041Ba-10MG","price":3335.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53052978332013,"sku":"CSB-NP078041Ba-1MG","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-NP078041Ba-SDS.jpg?v=1772166488","url":"https:\/\/www.ebiohippo.com\/products\/streptolysin-o-protein-bhp10506052","provider":"BioHippo","version":"1.0","type":"link"}