{"product_id":"strip1-antibody-striatin-interacting-protein-1-bha17135568","title":"STRIP1 Antibody \/ Striatin-interacting protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTRIP1 Antibody \/ Striatin-interacting protein 1 is a anti-STRIP1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STRIP1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IP, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTRIP1 antibody detects Striatin-interacting protein 1, a core component of the STRIPAK complex that integrates signaling, cytoskeletal organization, and cell migration. STRIP1 acts as a scaffold linking the PP2A phosphatase complex with kinases, adaptors, and actin-regulating proteins. The STRIP1 antibody is widely used in cell signaling, neurobiology, and cancer research to study cytoskeletal remodeling, phosphatase signaling, and morphogenesis.\u003cbr\u003e\u003cbr\u003eSTRIP1 is encoded by the STRIP1 gene located on human chromosome 3q22.1. The protein is approximately 837 amino acids long and forms stable interactions with striatin, PP2A, MOB4, and kinases of the GCKIII family. STRIP1 localizes to both cytoplasmic and cortical compartments, particularly in regions of actin remodeling and cell junctions.\u003cbr\u003e\u003cbr\u003eThe STRIP1 antibody detects a 95 kilodalton protein by western blot and exhibits perinuclear and cortical staining by immunofluorescence microscopy. STRIP1 regulates the activity of PP2A-dependent phosphatase signaling pathways that control cell polarity, adhesion, and migration. It acts in concert with STRN3 and STRN4 to modulate kinases such as STK24 and STK25, thereby maintaining cytoskeletal balance and tissue architecture.\u003cbr\u003e\u003cbr\u003eDisruption of STRIP1 impairs cell migration and polarity, leading to developmental abnormalities and cancer metastasis. Studies show that loss of STRIP1 alters actin stress fiber organization and cell junction stability, while overexpression promotes invasive behavior in tumor cells. In neurons, STRIP1 contributes to dendritic spine morphogenesis and synaptic plasticity through modulation of PP2A and Rho GTPase signaling.\u003cbr\u003e\u003cbr\u003eBecause STRIP1 functions as a molecular integrator connecting phosphatase signaling with cytoskeletal regulation, it serves as a crucial factor in understanding morphogenesis and disease progression.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STRIP1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STRIP1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STRIP1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STRIP1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STRIP1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047295541613,"sku":"FY12665","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_528f91e4-169e-4c81-83a7-3807a080efe8.jpg?v=1782237028","url":"https:\/\/www.ebiohippo.com\/products\/strip1-antibody-striatin-interacting-protein-1-bha17135568","provider":"BioHippo","version":"1.0","type":"link"}